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Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 12699
TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM720778(US20250051367, Compound 1)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM720779(Synthesis of (R)-4-phenyl-1-((R)-2-(pyrazine-2-car...)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM720788(Synthesis of ((R)-1-((R)-3-(oxazol-2-yl)-2-(pyrazi...)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM720789(US20250051367, Compound 12)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM720787(US20250051367, Compound 10)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM720782(US20250051367, Compound 5)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM720783(Synthesis of ((R)-1-((R)-3-(oxazol-5-yl)-2-(pyrazi...)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM720780(US20250051367, Compound 3)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM720781(Synthesis of ((R)-1-((R)-3-(1-methyl-1H-pyrazol-3-...)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM720790(Synthesis of ((R)-1-((R)-3-(1-methyl-1H-Imidazol-2...)
Affinity DataIC50: 275nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM720786(Synthesis of ((R)-3-methyl-1-((R)-3-(1-methyl-1H-I...)
Affinity DataIC50: 275nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM720784(US20250051367, Compound 7)
Affinity DataIC50: 275nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM720785(US20250051367, Compound 8)
Affinity DataIC50: 275nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent