Compile Data Set for Download or QSAR
Report error Found 283 Enz. Inhib. hit(s) with all data for entry = 13240
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770046(N-(4-(4-((1-methyl-1H- pyrazol-5- yl)methyl)pipera...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770047(N-(4-(4-(2,2- dimethylcyclopropane-1- carbonyl)pip...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770048(N-(4-(4-(2-methoxy-2- methylpropyl)piperazin-1- yl...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770049(N-(3-amino-4-(4- cyclopentylpiperazin-1- yl)phenyl...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770050(N-(4-(4-(2- cyclopropylacetyl)piperazin- 1-yl)phen...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770052(N-(4-(4- (cyclobutanecarbonyl) piperazin- 1-yl)phe...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770053(N-(4-(4-isobutyrylpiperazin- 1-yl)phenyl)-4-((8-me...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770055(N-(4-(4-(3,3- dimethylazetidine-1- carbonyl)pipera...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770056(N-(4-(4-(3,3- difluorocyclobutane-1- carbonyl)pipe...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770057(N-(4-(4-(3,3- difluoroazetidine-1- carbonyl)pipera...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770058(N-(4-(4-(2- azaspiro[3.3]heptane-2- carbonyl)piper...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770031(N-(4-(4-(2- methoxyethyl)piperazin-1-yl)- 3-methyl...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770032(N-(3-amino-4-(4- methylpiperazin-1-yl)phenyl)- 4-(...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770036(N-(4-(4-(2-(dimethylamino)- 2-oxoethyl)piperazin-1...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770038(N-(4-(4-(2-hydroxypropan-2- yl)piperidin-1-yl)phen...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770040(N-(4-(4-(1- hydroxyethyl)piperidin-1- yl)phenyl)-4...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770041(N-(4-(4-(1H-pyrazole-5- carbonyl)piperazin-1- yl)p...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770042(N-(4-(4-(3,3- dimethylcyclobutane-1- carbonyl)pipe...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770043(4-((8-methyl-2,3-dihydro-1H- pyrido[2,3-b][1,4]oxa...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770044(4-((8-methyl-2,3-dihydro-1H- pyrido[2,3-b][1,4]oxa...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770045(4-((8-methyl-2,3-dihydro-1H- pyrido[2,3-b][1,4]oxa...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770078(4-((8-methyl-2,3-dihydro-1H- pyrido[2,3-b][1,4]oxa...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770079(4-((8-methyl-2,3-dihydro-1H- pyrido[2,3-b][1,4]oxa...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770080(N-(4-(4-(2-fluoro-2- methylpropanoyl)piperazin-1- ...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770081((S)-N-(4-(4-isobutyryl-3- methylpiperazin-1-yl)phe...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770082(N-(4-(4-(2-methoxy-2- methylpropanoyl)piperazin-1-...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770083((S)-4-((8-methyl-2,3-dihydro- 1H-pyrido[2,3-b][1,4...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770084((S)-N-(4-(4-(2- methoxyethyl)-3- methylpiperazin-1...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770085((R)-4-((8-methyl-2,3-dihydro- 1H-pyrido[2,3-b][1,4...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770086((R)-N-(4-(4-(2- methoxyethyl)-3- methylpiperazin-1...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770087((R)-N-(4-(4-isobutyryl-3- methylpiperazin-1-yl)phe...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770088((S)-N-(4-(4-(2- methoxypropanoyl)piperazin- 1-yl)p...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770093(4-((8-methyl-2,3-dihydro-1H- pyrido[2,3-b][1,4]oxa...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770062(4-((8-methyl-2,3-dihydro-1H- pyrido[2,3-b][1,4]oxa...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM769880(N-(4-(4-hydroxypiperidin-1- yl)phenyl)-4-((8-methy...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770063(N-(4-(4-(azetidine-1- carbonyl)piperazin-1- yl)phe...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770064(4-((3,8-dimethyl-2,3-dihydro- 1H-pyrido[2,3-b][1,4...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM769878(4-((8-methyl-2,3-dihydro-1H- pyrido[2,3-b][1,4]oxa...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770065((S)-N-(4- (hexahydropyrazino[2,1- c][1,4]oxazin-8(...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM769877(N-(4-(4-(2- hydroxypropyl)piperazin-1- yl)phenyl)-...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770066((S)-N-(4- (hexahydropyrrolo[1,2- a]pyrazin-2(1H)-y...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM769876(N-(4-(4-(3- methoxypropyl)piperazin-1- yl)phenyl)-...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770067((R)-N-(4- (hexahydropyrrolo[1,2- a]pyrazin-2(1H)-y...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM769850(4-((3,8-dimethyl-2,3-dihydro- 1H-pyrido[2,3-b][1,4...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770070(N-(4-(4- (cyclopropanecarbonyl) piperazin-1-yl)phe...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM769835(N-(3-fluoro-4-(1-(2- methoxyethyl)piperidin-4- yl)...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770071(4-((8-methyl-2,3-dihydro-1H- pyrido[2,3-b][1,4]oxa...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770072(4-((8-methyl-2,3-dihydro-1H- pyrido[2,3-b][1,4]oxa...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM769825(N-(3-methyl-1,2,3,4,4a,5- hexahydrobenzo[b]pyrazin...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Curadev Pharma

US Patent
LigandPNGBDBM770074(N-(4-(4-(1-methyl-1H- pyrazol-3-yl)piperazin-1- yl...)
Affinity DataIC50: 10nMAssay Description:Compound inhibitory potency was measured in an HPK-1 kinase inhibition assay. Briefly, recombinant full length HPK-1 enzyme (6.8 nM) was incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

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