Compile Data Set for Download or QSAR
Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 13243
LigandPNGBDBM770211(4-(4-((1S,7S,8S)-8-chloro-5-oxa-2- azabicyclo[5.1....)
Affinity DataIC50: 7.14nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770195(5-ethynyl-6-fluoro-4-(8-fluoro-4- ((1S,7R,8S)-8-fl...)
Affinity DataIC50: 8.11nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770205(4-(4-((1S,7S,8S)-8-chloro-5-oxa-2- azabicyclo[5.1....)
Affinity DataIC50: 8.25nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770213(4-(4-((1S,7R,8S)-8-chloro-2- azabicyclo[5.1.0]octa...)
Affinity DataIC50: 9.04nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770196(5-ethynyl-6-fluoro-4-(8-fluoro-4- ((1S,7S,8S)-8-fl...)
Affinity DataIC50: 9.92nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770192(5-ethynyl-6,7-difluoro-4-(8-fluoro-4- ((1S,7R,8S)-...)
Affinity DataIC50: 9.98nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770193(5-ethynyl-6,7-difluoro-4-(8-fluoro-4- ((1S,7S,8S)-...)
Affinity DataIC50: 11.6nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770200(5-ethynyl-6-fluoro-4-(8-fluoro-4- ((1S,7S,8S)-8-fl...)
Affinity DataIC50: 11.7nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770208(4-(4-((1R,7S,8R)-8-chloro-2-oxa-6- azabicyclo[5.1....)
Affinity DataIC50: 14.1nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770187(4-(4-((1R,7S)-2-azabicyclo[5.1.0]octan-2- yl)-8-fl...)
Affinity DataIC50: 24.2nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770197(5-ethynyl-6,7-difluoro-4-(8-fluoro-4- ((1S,7R,8S)-...)
Affinity DataIC50: 27.4nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770188(4-(4-((1R,7S)-2-azabicyclo[5.1.0]octan-2- yl)-8-fl...)
Affinity DataIC50: 27.5nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770195(5-ethynyl-6-fluoro-4-(8-fluoro-4- ((1S,7R,8S)-8-fl...)
Affinity DataIC50: 39.2nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770211(4-(4-((1S,7S,8S)-8-chloro-5-oxa-2- azabicyclo[5.1....)
Affinity DataIC50: 50.1nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770208(4-(4-((1R,7S,8R)-8-chloro-2-oxa-6- azabicyclo[5.1....)
Affinity DataIC50: 51.2nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770205(4-(4-((1S,7S,8S)-8-chloro-5-oxa-2- azabicyclo[5.1....)
Affinity DataIC50: 52.6nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770200(5-ethynyl-6-fluoro-4-(8-fluoro-4- ((1S,7S,8S)-8-fl...)
Affinity DataIC50: 53.7nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770213(4-(4-((1S,7R,8S)-8-chloro-2- azabicyclo[5.1.0]octa...)
Affinity DataIC50: 54.7nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770192(5-ethynyl-6,7-difluoro-4-(8-fluoro-4- ((1S,7R,8S)-...)
Affinity DataIC50: 56.6nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770196(5-ethynyl-6-fluoro-4-(8-fluoro-4- ((1S,7S,8S)-8-fl...)
Affinity DataIC50: 60nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770194(4-(4-((1R,7S)-5-oxa-2- azabicyclo[5.1.0]octan-2-yl...)
Affinity DataIC50: 62.6nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770193(5-ethynyl-6,7-difluoro-4-(8-fluoro-4- ((1S,7S,8S)-...)
Affinity DataIC50: 89.7nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770197(5-ethynyl-6,7-difluoro-4-(8-fluoro-4- ((1S,7R,8S)-...)
Affinity DataIC50: 155nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770188(4-(4-((1R,7S)-2-azabicyclo[5.1.0]octan-2- yl)-8-fl...)
Affinity DataIC50: 213nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770187(4-(4-((1R,7S)-2-azabicyclo[5.1.0]octan-2- yl)-8-fl...)
Affinity DataIC50: 234nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770203(5-ethynyl-6-fluoro-4-(8-fluoro-4- ((1S,7S,8R)-8-fl...)
Affinity DataIC50: 264nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770189(5-ethynyl-6,7-difluoro-4-(8-fluoro-4- ((1S,7R,8R)-...)
Affinity DataIC50: 430nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770194(4-(4-((1R,7S)-5-oxa-2- azabicyclo[5.1.0]octan-2-yl...)
Affinity DataIC50: 443nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770206(4-(4-((1R,7R,8R)-8-chloro-5-oxa-2- azabicyclo[5.1....)
Affinity DataIC50: 648nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770204(4-(4-((1S,7S,8R)-8-chloro-5-oxa-2- azabicyclo[5.1....)
Affinity DataIC50: 1.39E+3nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770207(4-(4-((1R,7R,8S)-8-chloro-5-oxa-2- azabicyclo[5.1....)
Affinity DataIC50: 1.67E+3nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770212(4-(4-((1R,7S,8R)-8-chloro-2- azabicyclo[5.1.0]octa...)
Affinity DataIC50: 1.79E+3nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770215(4-(4-((1S,7R,8R)-8-chloro-2- azabicyclo[5.1.0]octa...)
Affinity DataIC50: 1.93E+3nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770189(5-ethynyl-6,7-difluoro-4-(8-fluoro-4- ((1S,7R,8R)-...)
Affinity DataIC50: 2.83E+3nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770203(5-ethynyl-6-fluoro-4-(8-fluoro-4- ((1S,7S,8R)-8-fl...)
Affinity DataIC50: 2.91E+3nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770204(4-(4-((1S,7S,8R)-8-chloro-5-oxa-2- azabicyclo[5.1....)
Affinity DataIC50: 3.00E+3nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770206(4-(4-((1R,7R,8R)-8-chloro-5-oxa-2- azabicyclo[5.1....)
Affinity DataIC50: 3.00E+3nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770207(4-(4-((1R,7R,8S)-8-chloro-5-oxa-2- azabicyclo[5.1....)
Affinity DataIC50: 3.00E+3nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770209(4-(4-((1S,7R,8S)-8-chloro-2-oxa-6- azabicyclo[5.1....)
Affinity DataIC50: 3.00E+3nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770209(4-(4-((1S,7R,8S)-8-chloro-2-oxa-6- azabicyclo[5.1....)
Affinity DataIC50: 3.00E+3nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770210(4-(4-((1R,7R,8R)-8-chloro-5-oxa-2- azabicyclo[5.1....)
Affinity DataIC50: 3.00E+3nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770214(4-(4-((1R,7S,8S)-8-chloro-2- azabicyclo[5.1.0]octa...)
Affinity DataIC50: 3.00E+3nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770199(5-ethynyl-6-fluoro-4-(8-fluoro-4- ((1R,7R,8R)-8-fl...)
Affinity DataIC50: 3.00E+3nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770199(5-ethynyl-6-fluoro-4-(8-fluoro-4- ((1R,7R,8R)-8-fl...)
Affinity DataIC50: 3.00E+3nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770201(5-ethynyl-6-fluoro-4-(8-fluoro-4- ((1R,7R,8R)-8-fl...)
Affinity DataIC50: 3.00E+3nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770201(5-ethynyl-6-fluoro-4-(8-fluoro-4- ((1R,7R,8R)-8-fl...)
Affinity DataIC50: 3.00E+3nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770202(5-ethynyl-6-fluoro-4-(8-fluoro-4- ((1R,7R,8S)-8-fl...)
Affinity DataIC50: 3.00E+3nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770202(5-ethynyl-6-fluoro-4-(8-fluoro-4- ((1R,7R,8S)-8-fl...)
Affinity DataIC50: 3.00E+3nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770212(4-(4-((1R,7S,8R)-8-chloro-2- azabicyclo[5.1.0]octa...)
Affinity DataIC50: 1.00E+4nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM770190(5-ethynyl-6,7-difluoro-4-(8-fluoro-4- ((1R,7S,8S)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

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