Compile Data Set for Download or QSAR
Report error Found 238 Enz. Inhib. hit(s) with all data for entry = 13349
TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782944(ethyl N-methyl-N-(2-oxo-4-(o-tolyl)-2H-chromen-7-y...)
Affinity DataIC50: 20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782943(isopropyl N-methyl-N-(2-oxo-4-(o-tolyl)-2H-chromen...)
Affinity DataIC50: 20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782945(methyl N-methyl-N-(2-oxo-4-(o-tolyl)-2H-chromen-7-...)
Affinity DataIC50: 30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM783007(7-((isoxazol-3-ylmethyl)(methyl)amino)-4-(o-tolyl)...)
Affinity DataIC50: 30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782877((S)-1-(N-methyl-N-(2-oxo-4-(o-tolyl)-2H-chromen-7-...)
Affinity DataIC50: 30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782930(2,2-dimethyl-3-(methyl(2-oxo-4-(o-tolyl)-2H-chrome...)
Affinity DataIC50: 30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782910(N-methyl-N-(2-oxo-4-(o-tolyl)-2H-chromen-7-yl)-D-a...)
Affinity DataIC50: 40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782872(tert-butyl N-methyl-N-(2-oxo-4-(o-tolyl)-2H-chrome...)
Affinity DataIC50: 40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782848(Synthesis of (R)-4-(2-chloro-4-fluorophenyl)-7-(me...)
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782928(7-(benzylamino)-4-(o-tolyl)-2H-chromen-2-one | US2...)
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782847(Synthesis of (R)-4-(2-chloro-4-fluorophenyl)-7-(me...)
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782999(2-(methyl(2-oxo-4-(o-tolyl)-2H-chromen-7-yl)amino)...)
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782982(7-(((1H-pyrazol-5-yl)methyl)(methyl)amino)-4-(o-to...)
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782981(N-methyl-2-(methyl(2-oxo-4-(o-tolyl)-2H-chromen-7-...)
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782885((S)-1-(2-methyl-3-(2-oxo-4-(o-tolyl)-2H-chromen-7-...)
Affinity DataIC50: 60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782857((R)-4-(2-chloro-4-fluorophenyl)-7-(methyl(1-morpho...)
Affinity DataIC50: 70nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782864(7-(2-methyl-3-oxo-3-(piperidin-1-yl)propyl)-4-(o-t...)
Affinity DataIC50: 80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782992(7-(methyl(oxazol-2-ylmethyl)amino)-4-(o-tolyl)-2H-...)
Affinity DataIC50: 80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782972(7-(methyl(pyridin-2-ylmethyl)amino)-4-(o-tolyl)-2H...)
Affinity DataIC50: 90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782890(ethyl (S)-1-(2-methyl-3-(2-oxo-4-(o-tolyl)-2H-chro...)
Affinity DataIC50: 90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM783018(1-((methyl(2-oxo-4-(o-tolyl)-2H-chromen-7-yl)amino...)
Affinity DataIC50: 90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782927(7-(methyl((1-methyl-1H-pyrazol-3-yl)methyl)amino)-...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782991((S)-1-((R)-3-(4-(2-chloro-4-fluorophenyl)-2-oxo-2H...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782829((R)-4-(2-chloro-4-fluorophenyl)-7-((1-oxo-1-(piper...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782941(2-(methyl(2-oxo-4-(o-tolyl)-2H-chromen-7-yl)amino)...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM783021(2-(methyl(2-oxo-4-(o-tolyl)-2H-chromen-7-yl)amino)...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782891((S)-1-(2-methyl-3-(2-oxo-4-(o-tolyl)-2H-chromen-7-...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782971(7-(methyl(thiazol-2-ylmethyl)amino)-4-(o-tolyl)-2H...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782983(7-(((1H-tetrazol-5-yl)methyl)(methyl)amino)-4-(o-t...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM783030(4-(methyl((2-oxo-4-(o-tolyl)-2H-chromen-7-yl)methy...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782997(7-(methyl((1-methyl-1H-pyrazol-5-yl)methyl)amino)-...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782882((S)-1-((2-oxo-4-(o-tolyl)-2H-chromen-7-yl)-D-alany...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782946(3-(methyl(2-oxo-4-(o-tolyl)-2H-chromen-7-yl)amino)...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782929(2,2-dimethyl-3-((2-oxo-4-(o-tolyl)-2H-chromen-7-yl...)
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782896(1-(2-methyl-3-(2-oxo-4-(o-tolyl)-2H-chromen-7-yl)p...)
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782960(4-(methyl((2-oxo-4-(o-tolyl)-2H-chromen-7-yl)methy...)
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782894((S)-N-methyl-1-(2-methyl-3-(2-oxo-4-(o-tolyl)-2H-c...)
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM783020(N-(2-hydroxyethyl)-2-(methyl(2-oxo-4-(o-tolyl)-2H-...)
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782955(4-(((2-oxo-4-(o-tolyl)-2H-chromen-7-yl)methyl)carb...)
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM783019(N-(2-methoxyethyl)-2-(methyl(2-oxo-4-(o-tolyl)-2H-...)
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782858((R)-2-((4-(2-chloro-4-fluorophenyl)-2-oxo-2H-chrom...)
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782936(N-(2-amino-2-oxoethyl)-2-(methyl(2-oxo-4-(o-tolyl)...)
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM783031((R)-3-(methyl(2-oxo-4-(o-tolyl)-2H-chromen-7-yl)am...)
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM783029((S)-3-(methyl(2-oxo-4-(o-tolyl)-2H-chromen-7-yl)am...)
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782878(N-methyl-N-(2-oxo-4-(o-tolyl)-2H-chromen-7-yl)glyc...)
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782908(2-(methyl(2-oxo-4-(o-tolyl)-2H-chromen-7-yl)amino)...)
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782938(N-methyl-2-(2-oxo-4-(o-tolyl)-2H-chromen-7-yl)cycl...)
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782984((S)-2-(methyl(2-oxo-4-(o-tolyl)-2H-chromen-7-yl)am...)
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782854(2-methyl-3-[4-(o-tolyl)-2-oxo-chromen-7-yl]propano...)
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM782821((S)-4-(2-chloro-4-fluorophenyl)-7-(2-methyl-3-oxo-...)
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

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