Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 6153
TargetEpidermal growth factor receptor(Human)
Warner-Lambert

US Patent
LigandPNGBDBM112498(US8623883, No. 1)
Affinity DataIC50: 6.44nMpH: 7.4 T: 2°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Warner-Lambert

US Patent
LigandPNGBDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)
Affinity DataIC50: 6.90nMpH: 7.4 T: 2°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Warner-Lambert

US Patent
LigandPNGBDBM112500(US8623883, No. 6)
Affinity DataIC50: 9.87nMpH: 7.4 T: 2°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Warner-Lambert

US Patent
LigandPNGBDBM112501(US8623883, No. 7)
Affinity DataIC50: 11.3nMpH: 7.4 T: 2°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Warner-Lambert

US Patent
LigandPNGBDBM112504(US8623883, No. 10)
Affinity DataIC50: 12.1nMpH: 7.4 T: 2°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Warner-Lambert

US Patent
LigandPNGBDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)
Affinity DataIC50: 16.7nMpH: 7.4 T: 2°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Warner-Lambert

US Patent
LigandPNGBDBM112503(US8623883, No. 9)
Affinity DataIC50: 18.1nMpH: 7.4 T: 2°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Warner-Lambert

US Patent
LigandPNGBDBM112504(US8623883, No. 10)
Affinity DataIC50: 41.3nMpH: 7.4 T: 2°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Warner-Lambert

US Patent
LigandPNGBDBM112502(US8623883, No. 8)
Affinity DataIC50: 45.3nMpH: 7.4 T: 2°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Warner-Lambert

US Patent
LigandPNGBDBM112501(US8623883, No. 7)
Affinity DataIC50: 61.5nMpH: 7.4 T: 2°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Warner-Lambert

US Patent
LigandPNGBDBM112498(US8623883, No. 1)
Affinity DataIC50: 77.5nMpH: 7.4 T: 2°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Warner-Lambert

US Patent
LigandPNGBDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)
Affinity DataIC50: 83.7nMpH: 7.4 T: 2°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Warner-Lambert

US Patent
LigandPNGBDBM112501(US8623883, No. 7)
Affinity DataIC50: 84.0nMpH: 7.4 T: 2°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Warner-Lambert

US Patent
LigandPNGBDBM112504(US8623883, No. 10)
Affinity DataIC50: 86.0nMpH: 7.4 T: 2°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Warner-Lambert

US Patent
LigandPNGBDBM112503(US8623883, No. 9)
Affinity DataIC50: 147nMpH: 7.4 T: 2°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Warner-Lambert

US Patent
LigandPNGBDBM112500(US8623883, No. 6)
Affinity DataIC50: 154nMpH: 7.4 T: 2°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Warner-Lambert

US Patent
LigandPNGBDBM112502(US8623883, No. 8)
Affinity DataIC50: 212nMpH: 7.4 T: 2°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Warner-Lambert

US Patent
LigandPNGBDBM112502(US8623883, No. 8)
Affinity DataIC50: 234nMpH: 7.4 T: 2°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Warner-Lambert

US Patent
LigandPNGBDBM112500(US8623883, No. 6)
Affinity DataIC50: 244nMpH: 7.4 T: 2°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Warner-Lambert

US Patent
LigandPNGBDBM112503(US8623883, No. 9)
Affinity DataIC50: 247nMpH: 7.4 T: 2°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent