Compile Data Set for Download or QSAR
Report error Found 226 Enz. Inhib. hit(s) with all data for entry = 6824
TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153166BDBM153166(US8993756, 4-9)
Affinity DataIC50: 0.0130nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153198BDBM153198(US8993756, 5-10)
Affinity DataIC50: 0.0130nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153227BDBM153227(US8993756, 20-9 | US10421760, Comparative Example ...)
Affinity DataIC50: 0.0160nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 47231BDBM47231(US8993756, 16)
Affinity DataIC50: 0.0200nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153218BDBM153218(US8993756, 15-2)
Affinity DataIC50: 0.0200nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153191BDBM153191(US8993756, 5-1)
Affinity DataIC50: 0.0240nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153217BDBM153217(US8993756, 15-1)
Affinity DataIC50: 0.0240nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153207BDBM153207(US8993756, 5-45)
Affinity DataIC50: 0.0250nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153168BDBM153168(US8993756, 4-11)
Affinity DataIC50: 0.0330nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153209BDBM153209(US8993756, 10-1)
Affinity DataIC50: 0.0370nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153163BDBM153163(US8993756, 4-5)
Affinity DataIC50: 0.0400nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153194BDBM153194(US8993756, 5-5)
Affinity DataIC50: 0.0430nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153162BDBM153162(US8993756, 4-4)
Affinity DataIC50: 0.0490nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153190BDBM153190(US8993756, 4-35)
Affinity DataIC50: 0.0490nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153175BDBM153175(US8993756, 4-19)
Affinity DataIC50: 0.0500nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153214BDBM153214(US8993756, 13-1)
Affinity DataIC50: 0.0520nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153219BDBM153219(US8993756, 18-1)
Affinity DataIC50: 0.0560nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153170BDBM153170(US8993756, 4-14)
Affinity DataIC50: 0.0660nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153179BDBM153179(US8993756, 4-24)
Affinity DataIC50: 0.0680nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153172BDBM153172(US8993756, 4-16)
Affinity DataIC50: 0.0700nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153193BDBM153193(US8993756, 5-3)
Affinity DataIC50: 0.0720nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153176BDBM153176(US8993756, 4-20)
Affinity DataIC50: 0.0810nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153161BDBM153161(US8993756, 4-3)
Affinity DataIC50: 0.0850nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153184BDBM153184(US8993756, 4-29)
Affinity DataIC50: 0.0870nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153180BDBM153180(US8993756, 4-25)
Affinity DataIC50: 0.110nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153174BDBM153174(BDBM153192 | US8993756, 4-18)
Affinity DataIC50: 0.110nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153174BDBM153174(BDBM153192 | US8993756, 4-18)
Affinity DataIC50: 0.110nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153186BDBM153186(US8993756, 4-31)
Affinity DataIC50: 0.110nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153171BDBM153171(US8993756, 4-15)
Affinity DataIC50: 0.110nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153173BDBM153173(US8993756, 4-17)
Affinity DataIC50: 0.110nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153213BDBM153213(US8993756, 12-1)
Affinity DataIC50: 0.130nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153204BDBM153204(US8993756, 5-36)
Affinity DataIC50: 0.140nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153182BDBM153182(US8993756, 4-27)
Affinity DataIC50: 0.140nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153159BDBM153159(BDBM153160 | US8993756, 4-1)
Affinity DataIC50: 0.150nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153167BDBM153167(US8993756, 4-10)
Affinity DataIC50: 0.150nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153220BDBM153220(US8993756, 20-1)
Affinity DataIC50: 0.170nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153181BDBM153181(US8993756, 4-26)
Affinity DataIC50: 0.190nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153169BDBM153169(US8993756, 4-12)
Affinity DataIC50: 0.190nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153195BDBM153195(US8993756, 5-6)
Affinity DataIC50: 0.220nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153178BDBM153178(US8993756, 4-23)
Affinity DataIC50: 0.340nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153211BDBM153211(US8993756, 11-1)
Affinity DataIC50: 0.400nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153188BDBM153188(US8993756, 4-33)
Affinity DataIC50: 0.470nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153221BDBM153221(US8993756, 20-2)
Affinity DataIC50: 0.590nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153165BDBM153165(US8993756, 4-8)
Affinity DataIC50: 0.610nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153206BDBM153206(US8993756, 5-41)
Affinity DataIC50: 0.660nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153187BDBM153187(US8993756, 4-32)
Affinity DataIC50: 0.680nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153222BDBM153222(US8993756, 20-3)
Affinity DataIC50: 0.960nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153189BDBM153189(US8993756, 4-34)
Affinity DataIC50: 1.10nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153236BDBM153236(US8993756, 33-3)
Affinity DataIC50: 1.40nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 153224BDBM153224(US8993756, 20-5)
Affinity DataIC50: 1.5nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
US Patent

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