Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 7657
TargetTransient receptor potential M8 protein(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM209011(Piperidine-1-sulfonic acid (3-methyl-benzo[b]thiop...)
Affinity DataIC50: 3.60nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetTransient receptor potential M8 protein(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM209017(1-[(3-Methyl-benzo[b]thiophen-2-yl)-(4-trifluorome...)
Affinity DataIC50: 4.60nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetTransient receptor potential M8 protein(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM209012(Morpholine-1-sulfonic acid (3-methyl-benzo[b]thiop...)
Affinity DataIC50: 5.70nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetTransient receptor potential M8 protein(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM209021(N-(3-Bromo-benzo[b]thiophen-2-yl)-N-(4-fluoro-3-tr...)
Affinity DataIC50: 8.5nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetTransient receptor potential M8 protein(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM209022(4-(2,2,2-Trifluoro-ethyl)-piperazine-1-sulfonic ac...)
Affinity DataIC50: 13nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetTransient receptor potential M8 protein(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM209020(N-(3-Bromo-benzo[b]thiophen-2-yl)-N-(4-fluoro-3-tr...)
Affinity DataIC50: 18nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetTransient receptor potential M8 protein(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM209015(4-Methyl-piperazine-1-sulfonic acid (3-methyl-benz...)
Affinity DataIC50: 46nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetTransient receptor potential M8 protein(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM209013(4-Isopropyl-piperazine-1-sulfonic acid (3-methyl-b...)
Affinity DataIC50: 60nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetTransient receptor potential M8 protein(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM209018(1-[(3-Methyl-benzo[b]thiophen-2-yl)-(4-trifluorome...)
Affinity DataIC50: 61nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetTransient receptor potential M8 protein(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM209019(N-(4-Fluoro-3-trifluoromethyl-benzyl)-N-(3-methyl-...)
Affinity DataIC50: 62nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetTransient receptor potential M8 protein(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM209014(4-(3-Methyl-butyl)-piperazine-1-sulfonic acid (3-m...)
Affinity DataIC50: 71nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent