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Found 18 Enz. Inhib. hit(s) with all data for entry = 7635
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Thesan Pharmaceuticals

US Patent
LigandPNGBDBM172452(US9090625, 4 | US9260450, 4 | US9938289, 4)
Affinity DataIC50:  4.33nMpH: 7.6 T: 2°CAssay Description:In a 96 well filter-bottom plate (Millipore, #MSDV N6B 50), 58 ul Assay Buffer (50 mM HEPES, pH 7.6, with 10 mM NaCl, 10 mM MgCl2, and 1 mM DTT ) is ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Thesan Pharmaceuticals

US Patent
LigandPNGBDBM172455(US9090625, 7 | US9260450, 7 | US9938289, 7)
Affinity DataIC50:  6.65nMpH: 7.6 T: 2°CAssay Description:In a 96 well filter-bottom plate (Millipore, #MSDV N6B 50), 58 ul Assay Buffer (50 mM HEPES, pH 7.6, with 10 mM NaCl, 10 mM MgCl2, and 1 mM DTT ) is ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Thesan Pharmaceuticals

US Patent
LigandPNGBDBM172457(US9090625, 12 | US9260450, 12 | US9938289, 12)
Affinity DataIC50:  7.94nMpH: 7.6 T: 2°CAssay Description:In a 96 well filter-bottom plate (Millipore, #MSDV N6B 50), 58 ul Assay Buffer (50 mM HEPES, pH 7.6, with 10 mM NaCl, 10 mM MgCl2, and 1 mM DTT ) is ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Thesan Pharmaceuticals

US Patent
LigandPNGBDBM172453(US9090625, 5 | US9260450, 5 | US9938289, 5)
Affinity DataIC50:  12.9nMpH: 7.6 T: 2°CAssay Description:In a 96 well filter-bottom plate (Millipore, #MSDV N6B 50), 58 ul Assay Buffer (50 mM HEPES, pH 7.6, with 10 mM NaCl, 10 mM MgCl2, and 1 mM DTT ) is ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Thesan Pharmaceuticals

US Patent
LigandPNGBDBM172458(US9090625, 13 | US9260450, 13 | US9938289, 13)
Affinity DataIC50:  18.9nMpH: 7.6 T: 2°CAssay Description:In a 96 well filter-bottom plate (Millipore, #MSDV N6B 50), 58 ul Assay Buffer (50 mM HEPES, pH 7.6, with 10 mM NaCl, 10 mM MgCl2, and 1 mM DTT ) is ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Thesan Pharmaceuticals

US Patent
LigandPNGBDBM172452(US9090625, 4 | US9260450, 4 | US9938289, 4)
Affinity DataIC50:  21.5nMAssay Description:ALK-5 gene reporter assay methods have been described in the art (see e.g., Maliekal et al. (2004) J Biol Chem 279(35):36287-36292). The compounds na...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Thesan Pharmaceuticals

US Patent
LigandPNGBDBM172449(US9090625, 1 | US9260450, 1 | US9938289, 1)
Affinity DataIC50:  23.4nMpH: 7.6 T: 2°CAssay Description:In a 96 well filter-bottom plate (Millipore, #MSDV N6B 50), 58 ul Assay Buffer (50 mM HEPES, pH 7.6, with 10 mM NaCl, 10 mM MgCl2, and 1 mM DTT ) is ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Thesan Pharmaceuticals

US Patent
LigandPNGBDBM172453(US9090625, 5 | US9260450, 5 | US9938289, 5)
Affinity DataIC50:  30.8nMAssay Description:ALK-5 gene reporter assay methods have been described in the art (see e.g., Maliekal et al. (2004) J Biol Chem 279(35):36287-36292). The compounds na...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Thesan Pharmaceuticals

US Patent
LigandPNGBDBM172454(US9090625, 6 | US9260450, 6 | US9938289, 6)
Affinity DataIC50:  35.2nMpH: 7.6 T: 2°CAssay Description:In a 96 well filter-bottom plate (Millipore, #MSDV N6B 50), 58 ul Assay Buffer (50 mM HEPES, pH 7.6, with 10 mM NaCl, 10 mM MgCl2, and 1 mM DTT ) is ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Thesan Pharmaceuticals

US Patent
LigandPNGBDBM172455(US9090625, 7 | US9260450, 7 | US9938289, 7)
Affinity DataIC50:  35.9nMAssay Description:ALK-5 gene reporter assay methods have been described in the art (see e.g., Maliekal et al. (2004) J Biol Chem 279(35):36287-36292). The compounds na...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Thesan Pharmaceuticals

US Patent
LigandPNGBDBM172457(US9090625, 12 | US9260450, 12 | US9938289, 12)
Affinity DataIC50:  42.5nMAssay Description:ALK-5 gene reporter assay methods have been described in the art (see e.g., Maliekal et al. (2004) J Biol Chem 279(35):36287-36292). The compounds na...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Thesan Pharmaceuticals

US Patent
LigandPNGBDBM172458(US9090625, 13 | US9260450, 13 | US9938289, 13)
Affinity DataIC50:  57.5nMAssay Description:ALK-5 gene reporter assay methods have been described in the art (see e.g., Maliekal et al. (2004) J Biol Chem 279(35):36287-36292). The compounds na...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Thesan Pharmaceuticals

US Patent
LigandPNGBDBM172450(US9090625, 2 | US9260450, 2 | US9938289, 2)
Affinity DataIC50:  94.1nMpH: 7.6 T: 2°CAssay Description:In a 96 well filter-bottom plate (Millipore, #MSDV N6B 50), 58 ul Assay Buffer (50 mM HEPES, pH 7.6, with 10 mM NaCl, 10 mM MgCl2, and 1 mM DTT ) is ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Thesan Pharmaceuticals

US Patent
LigandPNGBDBM172451(US9090625, 3 | US9260450, 3 | US9938289, 3)
Affinity DataIC50:  108nMpH: 7.6 T: 2°CAssay Description:In a 96 well filter-bottom plate (Millipore, #MSDV N6B 50), 58 ul Assay Buffer (50 mM HEPES, pH 7.6, with 10 mM NaCl, 10 mM MgCl2, and 1 mM DTT ) is ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Thesan Pharmaceuticals

US Patent
LigandPNGBDBM172449(US9090625, 1 | US9260450, 1 | US9938289, 1)
Affinity DataIC50:  149nMAssay Description:ALK-5 gene reporter assay methods have been described in the art (see e.g., Maliekal et al. (2004) J Biol Chem 279(35):36287-36292). The compounds na...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Thesan Pharmaceuticals

US Patent
LigandPNGBDBM172454(US9090625, 6 | US9260450, 6 | US9938289, 6)
Affinity DataIC50:  244nMAssay Description:ALK-5 gene reporter assay methods have been described in the art (see e.g., Maliekal et al. (2004) J Biol Chem 279(35):36287-36292). The compounds na...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Thesan Pharmaceuticals

US Patent
LigandPNGBDBM172451(US9090625, 3 | US9260450, 3 | US9938289, 3)
Affinity DataIC50:  403nMAssay Description:ALK-5 gene reporter assay methods have been described in the art (see e.g., Maliekal et al. (2004) J Biol Chem 279(35):36287-36292). The compounds na...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Thesan Pharmaceuticals

US Patent
LigandPNGBDBM172450(US9090625, 2 | US9260450, 2 | US9938289, 2)
Affinity DataIC50:  440nMAssay Description:ALK-5 gene reporter assay methods have been described in the art (see e.g., Maliekal et al. (2004) J Biol Chem 279(35):36287-36292). The compounds na...More data for this Ligand-Target Pair
In DepthDetails US Patent