Compile Data Set for Download or QSAR
Report error Found 95 Enz. Inhib. hit(s) with all data for entry = 7811
TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 1nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 1nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 1nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 1nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8891(CHEMBL206351 | 3-(6-Methoxy-3,4-dihydronaphthalen-...)
Affinity DataIC50: 2nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8909(6-Pyridin-3-yl-2-naphthonitrile | 6-(pyridin-3-yl)...)
Affinity DataIC50: 3nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM220126(US9271963, 34)
Affinity DataIC50: 4nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetAromatase(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8889(3-(3,4-Dihydronaphthalen-2-yl)pyridine | Dihydrona...)
Affinity DataIC50: 4.07nMpH: 7.4Assay Description:The enzyme was obtained from the microsome fraction of fresh human placenta (St. Josephs Krankenhaus, Saarbrucken-Dudweiler, Germany) according to th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8894(3-(3-Methyl-3,4-dihydronaphthalen-2-yl)pyridine | ...)
Affinity DataIC50: 5nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8905(3-(6-methoxynaphthalen-2-yl)pyridine | 3-(6-Methox...)
Affinity DataIC50: 6nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8905(3-(6-methoxynaphthalen-2-yl)pyridine | 3-(6-Methox...)
Affinity DataIC50: 6.20nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8892(3-(1-methyl-3,4-dihydronaphthalen-2-yl)pyridine | ...)
Affinity DataIC50: 7nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8889(3-(3,4-Dihydronaphthalen-2-yl)pyridine | Dihydrona...)
Affinity DataIC50: 7nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 9nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 9.70nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 10nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 10nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8908(3-(6-Ethoxy-2-naphthyl)pyridine | 3-(6-ethoxynapht...)
Affinity DataIC50: 12nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8910(3-(5-chloro-6-methoxynaphthalen-2-yl)pyridine | 3-...)
Affinity DataIC50: 13nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8895(3-(4-Methyl-3,4-dihydronaphthalen-2-yl)pyridine | ...)
Affinity DataIC50: 13nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8888(3-(1H-Inden-2-yl)pyridine | indene 1 | US9271963, ...)
Affinity DataIC50: 13.5nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8907(3-(6-Bromo-2-naphthyl)pyridine | 3-(6-bromonaphtha...)
Affinity DataIC50: 15nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 18.7nMpH: 7.4 T: 2°CAssay Description:A suspension of fission yeast (S. pombe PE1) with a cell density of 3˙10^7 cells/ml was prepared on a freshly grown culture using fresh EMMG (pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8906(6-Pyridin-3-ylnaphthalen-2-ol | 6-(pyridin-3-yl)na...)
Affinity DataIC50: 23nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8913(3-(1-chloro-7-methoxynaphthalen-2-yl)pyridine | 3-...)
Affinity DataIC50: 27nMpH: 7.4 T: 2°CAssay Description:A solution of 6.25 nmol of progesterone (in 5 μl of MeOH) was dissolved in 140 μl of phosphate buffer (0.05 M; pH 7.4; 1 mM MgCl2; 0.1 mM EDTA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8912(3-(1,5-Dichloro-6-methoxy-2-naphthyl)pyridine | 3-...)
Affinity DataIC50: 28nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8904(3-(2-Naphthyl)pyridine | 3-(naphthalen-2-yl)pyridi...)
Affinity DataIC50: 28nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 28.3nMpH: 7.4 T: 2°CAssay Description:A suspension of fission yeast (S. pombe PE1) with a cell density of 3˙10^7 cells/ml was prepared on a freshly grown culture using fresh EMMG (pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8904(3-(2-Naphthyl)pyridine | 3-(naphthalen-2-yl)pyridi...)
Affinity DataIC50: 28.4nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8913(3-(1-chloro-7-methoxynaphthalen-2-yl)pyridine | 3-...)
Affinity DataIC50: 29nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetAromatase(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 29.5nMpH: 7.4Assay Description:The enzyme was obtained from the microsome fraction of fresh human placenta (St. Josephs Krankenhaus, Saarbrucken-Dudweiler, Germany) according to th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetAromatase(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 30nMpH: 7.4Assay Description:The enzyme was obtained from the microsome fraction of fresh human placenta (St. Josephs Krankenhaus, Saarbrucken-Dudweiler, Germany) according to th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8893(3-(1-ethyl-3,4-dihydronaphthalen-2-yl)pyridine | 3...)
Affinity DataIC50: 30nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetAromatase(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataIC50: 30nMpH: 7.4Assay Description:The enzyme was obtained from the microsome fraction of fresh human placenta (St. Josephs Krankenhaus, Saarbrucken-Dudweiler, Germany) according to th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8911(3-(5-Bromo-6-methoxy-2-naphthyl)pyridine | 3-(5-br...)
Affinity DataIC50: 33nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8916(1-(2-Naphthyl)-1H-imidazole | 1-(naphthalen-2-yl)-...)
Affinity DataIC50: 38nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8917(1-(3-methoxynaphthalen-2-yl)-1H-imidazole | Imidaz...)
Affinity DataIC50: 40nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8914(methyl 6-(pyridin-3-yl)naphthalene-2-carboxylate |...)
Affinity DataIC50: 73nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM151585(US8987315, Ketoconazole | US9180183, Ketoconazole ...)
Affinity DataIC50: 80.5nMpH: 7.4 T: 2°CAssay Description:A solution of 6.25 nmol of progesterone (in 5 μl of MeOH) was dissolved in 140 μl of phosphate buffer (0.05 M; pH 7.4; 1 mM MgCl2; 0.1 mM EDTA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM151585(US8987315, Ketoconazole | US9180183, Ketoconazole ...)
Affinity DataIC50: 81nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM151585(US8987315, Ketoconazole | US9180183, Ketoconazole ...)
Affinity DataIC50: 81nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8905(3-(6-methoxynaphthalen-2-yl)pyridine | 3-(6-Methox...)
Affinity DataIC50: 100nMpH: 7.4 T: 2°CAssay Description:A suspension of fission yeast (S. pombe PE1) with a cell density of 3˙10^7 cells/ml was prepared on a freshly grown culture using fresh EMMG (pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetAromatase(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8917(1-(3-methoxynaphthalen-2-yl)-1H-imidazole | Imidaz...)
Affinity DataIC50: 129nMpH: 7.4Assay Description:The enzyme was obtained from the microsome fraction of fresh human placenta (St. Josephs Krankenhaus, Saarbrucken-Dudweiler, Germany) according to th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8904(3-(2-Naphthyl)pyridine | 3-(naphthalen-2-yl)pyridi...)
Affinity DataIC50: 164nMpH: 7.4 T: 2°CAssay Description:A suspension of fission yeast (S. pombe PE1) with a cell density of 3˙10^7 cells/ml was prepared on a freshly grown culture using fresh EMMG (pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM220125(US9271963, 27)
Affinity DataIC50: 206nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8891(CHEMBL206351 | 3-(6-Methoxy-3,4-dihydronaphthalen-...)
Affinity DataIC50: 213nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM151585(US8987315, Ketoconazole | US9180183, Ketoconazole ...)
Affinity DataIC50: 224nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM151585(US8987315, Ketoconazole | US9180183, Ketoconazole ...)
Affinity DataIC50: 224nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8912(3-(1,5-Dichloro-6-methoxy-2-naphthyl)pyridine | 3-...)
Affinity DataIC50: 233nMpH: 7.4 T: 2°CAssay Description:A solution of 6.25 nmol of progesterone (in 5 μl of MeOH) was dissolved in 140 μl of phosphate buffer (0.05 M; pH 7.4; 1 mM MgCl2; 0.1 mM EDTA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Universitat Des Saarlandes

US Patent
LigandPNGBDBM8889(3-(3,4-Dihydronaphthalen-2-yl)pyridine | Dihydrona...)
Affinity DataIC50: 411nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

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