Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 7814
LigandPNGBDBM50143320(2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]hept...)
Affinity DataKi:  0.0180nM ΔG°:  -61.3kJ/molepH: 7.4 T: 2°CAssay Description:Adult male rat cerebral cortices (Pelfreeze Biological, Rogers, Ark.) were homogenized in 39 volumes of ice-cold 50 mM Tris buffer (pH 7.4 at 4° C.) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

LigandPNGBDBM221044(US9284322, Table 6, Compound 10)
Affinity DataKi:  0.0400nM ΔG°:  -59.3kJ/molepH: 7.4 T: 2°CAssay Description:Adult male rat cerebral cortices (Pelfreeze Biological, Rogers, Ark.) were homogenized in 39 volumes of ice-cold 50 mM Tris buffer (pH 7.4 at 4° C.) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

LigandPNGBDBM221036(US9284322, Table 6, Compound 2)
Affinity DataKi:  0.0490nM ΔG°:  -58.8kJ/molepH: 7.4 T: 2°CAssay Description:Adult male rat cerebral cortices (Pelfreeze Biological, Rogers, Ark.) were homogenized in 39 volumes of ice-cold 50 mM Tris buffer (pH 7.4 at 4° C.) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

LigandPNGBDBM221037(US9284322, Table 6, Compound 3)
Affinity DataKi:  0.0630nM ΔG°:  -58.2kJ/molepH: 7.4 T: 2°CAssay Description:Adult male rat cerebral cortices (Pelfreeze Biological, Rogers, Ark.) were homogenized in 39 volumes of ice-cold 50 mM Tris buffer (pH 7.4 at 4° C.) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

LigandPNGBDBM221041(US9284322, Table 6, Compound 7)
Affinity DataKi:  0.0670nM ΔG°:  -58.1kJ/molepH: 7.4 T: 2°CAssay Description:Adult male rat cerebral cortices (Pelfreeze Biological, Rogers, Ark.) were homogenized in 39 volumes of ice-cold 50 mM Tris buffer (pH 7.4 at 4° C.) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

LigandPNGBDBM221045(US9284322, Table 7, Compound 1)
Affinity DataKi:  0.120nM ΔG°:  -56.6kJ/molepH: 7.4 T: 2°CAssay Description:Adult male rat cerebral cortices (Pelfreeze Biological, Rogers, Ark.) were homogenized in 39 volumes of ice-cold 50 mM Tris buffer (pH 7.4 at 4° C.) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

LigandPNGBDBM221040(US9284322, Table 6, Compound 6)
Affinity DataKi:  0.120nM ΔG°:  -56.6kJ/molepH: 7.4 T: 2°CAssay Description:Adult male rat cerebral cortices (Pelfreeze Biological, Rogers, Ark.) were homogenized in 39 volumes of ice-cold 50 mM Tris buffer (pH 7.4 at 4° C.) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

LigandPNGBDBM221048(US9303017, Varenicline | US9284322, varenicline)
Affinity DataKi:  0.120nM ΔG°:  -56.6kJ/molepH: 7.4 T: 2°CAssay Description:Adult male rat cerebral cortices (Pelfreeze Biological, Rogers, Ark.) were homogenized in 39 volumes of ice-cold 50 mM Tris buffer (pH 7.4 at 4° C.) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM221043(US9284322, Table 6, Compound 9)
Affinity DataKi:  0.130nM ΔG°:  -56.4kJ/molepH: 7.4 T: 2°CAssay Description:Adult male rat cerebral cortices (Pelfreeze Biological, Rogers, Ark.) were homogenized in 39 volumes of ice-cold 50 mM Tris buffer (pH 7.4 at 4° C.) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

LigandPNGBDBM221039(US9284322, Table 6, Compound 5)
Affinity DataKi:  0.130nM ΔG°:  -56.4kJ/molepH: 7.4 T: 2°CAssay Description:Adult male rat cerebral cortices (Pelfreeze Biological, Rogers, Ark.) were homogenized in 39 volumes of ice-cold 50 mM Tris buffer (pH 7.4 at 4° C.) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

LigandPNGBDBM221038(US9284322, Table 6, Compound 4)
Affinity DataKi:  0.25nM ΔG°:  -54.8kJ/molepH: 7.4 T: 2°CAssay Description:Adult male rat cerebral cortices (Pelfreeze Biological, Rogers, Ark.) were homogenized in 39 volumes of ice-cold 50 mM Tris buffer (pH 7.4 at 4° C.) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

LigandPNGBDBM221049(US9284322, Table 7, Compound 3)
Affinity DataKi:  0.320nM ΔG°:  -54.2kJ/molepH: 7.4 T: 2°CAssay Description:Adult male rat cerebral cortices (Pelfreeze Biological, Rogers, Ark.) were homogenized in 39 volumes of ice-cold 50 mM Tris buffer (pH 7.4 at 4° C.) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

LigandPNGBDBM221035(US9284322, Table 6, Compound 1)
Affinity DataKi:  0.350nM ΔG°:  -54.0kJ/molepH: 7.4 T: 2°CAssay Description:Adult male rat cerebral cortices (Pelfreeze Biological, Rogers, Ark.) were homogenized in 39 volumes of ice-cold 50 mM Tris buffer (pH 7.4 at 4° C.) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

LigandPNGBDBM221046(US9284322, Table 7, Compound 2)
Affinity DataKi:  0.840nM ΔG°:  -51.8kJ/molepH: 7.4 T: 2°CAssay Description:Adult male rat cerebral cortices (Pelfreeze Biological, Rogers, Ark.) were homogenized in 39 volumes of ice-cold 50 mM Tris buffer (pH 7.4 at 4° C.) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

LigandPNGBDBM221042(US9284322, Table 6, Compound 8)
Affinity DataKi:  1.18nM ΔG°:  -51.0kJ/molepH: 7.4 T: 2°CAssay Description:Adult male rat cerebral cortices (Pelfreeze Biological, Rogers, Ark.) were homogenized in 39 volumes of ice-cold 50 mM Tris buffer (pH 7.4 at 4° C.) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

LigandPNGBDBM50004108((R,S)-nicotine | (RS)-nicotine | nicotine | (+-)-n...)
Affinity DataKi:  1.5nM ΔG°:  -50.4kJ/molepH: 7.4 T: 2°CAssay Description:Adult male rat cerebral cortices (Pelfreeze Biological, Rogers, Ark.) were homogenized in 39 volumes of ice-cold 50 mM Tris buffer (pH 7.4 at 4° C.) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

US Patent
LigandPNGBDBM221048(US9303017, Varenicline | US9284322, varenicline)
Affinity DataKi:  32.5nMpH: 7.4Assay Description:Adult male rat cerebral cortices (Pel-Freez Biologicals, Rogers, Ark.) were homogenized (polytron) in 39 volumes of ice-cold 50 mM Tris buffer (assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

US Patent
LigandPNGBDBM221045(US9284322, Table 7, Compound 1)
Affinity DataKi:  32.5nMpH: 7.4Assay Description:Adult male rat cerebral cortices (Pel-Freez Biologicals, Rogers, Ark.) were homogenized (polytron) in 39 volumes of ice-cold 50 mM Tris buffer (assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

US Patent
LigandPNGBDBM221049(US9284322, Table 7, Compound 3)
Affinity DataKi:  170nMpH: 7.4Assay Description:Adult male rat cerebral cortices (Pel-Freez Biologicals, Rogers, Ark.) were homogenized (polytron) in 39 volumes of ice-cold 50 mM Tris buffer (assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

US Patent
LigandPNGBDBM221039(US9284322, Table 6, Compound 5)
Affinity DataKi:  524nMpH: 7.4Assay Description:Adult male rat cerebral cortices (Pel-Freez Biologicals, Rogers, Ark.) were homogenized (polytron) in 39 volumes of ice-cold 50 mM Tris buffer (assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

US Patent
LigandPNGBDBM221043(US9284322, Table 6, Compound 9)
Affinity DataKi:  719nMpH: 7.4Assay Description:Adult male rat cerebral cortices (Pel-Freez Biologicals, Rogers, Ark.) were homogenized (polytron) in 39 volumes of ice-cold 50 mM Tris buffer (assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

US Patent
LigandPNGBDBM221038(US9284322, Table 6, Compound 4)
Affinity DataKi:  1.47E+3nMpH: 7.4Assay Description:Adult male rat cerebral cortices (Pel-Freez Biologicals, Rogers, Ark.) were homogenized (polytron) in 39 volumes of ice-cold 50 mM Tris buffer (assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

US Patent
LigandPNGBDBM221046(US9284322, Table 7, Compound 2)
Affinity DataKi:  1.93E+3nMpH: 7.4Assay Description:Adult male rat cerebral cortices (Pel-Freez Biologicals, Rogers, Ark.) were homogenized (polytron) in 39 volumes of ice-cold 50 mM Tris buffer (assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

US Patent
LigandPNGBDBM221036(US9284322, Table 6, Compound 2)
Affinity DataKi:  4.85E+3nMpH: 7.4Assay Description:Adult male rat cerebral cortices (Pel-Freez Biologicals, Rogers, Ark.) were homogenized (polytron) in 39 volumes of ice-cold 50 mM Tris buffer (assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

US Patent
LigandPNGBDBM221035(US9284322, Table 6, Compound 1)
Affinity DataKi:  5.50E+3nMpH: 7.4Assay Description:Adult male rat cerebral cortices (Pel-Freez Biologicals, Rogers, Ark.) were homogenized (polytron) in 39 volumes of ice-cold 50 mM Tris buffer (assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

US Patent
LigandPNGBDBM221037(US9284322, Table 6, Compound 3)
Affinity DataKi:  6.60E+3nMpH: 7.4Assay Description:Adult male rat cerebral cortices (Pel-Freez Biologicals, Rogers, Ark.) were homogenized (polytron) in 39 volumes of ice-cold 50 mM Tris buffer (assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

US Patent
LigandPNGBDBM221041(US9284322, Table 6, Compound 7)
Affinity DataKi:  7.30E+3nMpH: 7.4Assay Description:Adult male rat cerebral cortices (Pel-Freez Biologicals, Rogers, Ark.) were homogenized (polytron) in 39 volumes of ice-cold 50 mM Tris buffer (assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

US Patent
LigandPNGBDBM221044(US9284322, Table 6, Compound 10)
Affinity DataKi:  7.90E+3nMpH: 7.4Assay Description:Adult male rat cerebral cortices (Pel-Freez Biologicals, Rogers, Ark.) were homogenized (polytron) in 39 volumes of ice-cold 50 mM Tris buffer (assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

US Patent
LigandPNGBDBM221040(US9284322, Table 6, Compound 6)
Affinity DataKi:  9.70E+3nMpH: 7.4Assay Description:Adult male rat cerebral cortices (Pel-Freez Biologicals, Rogers, Ark.) were homogenized (polytron) in 39 volumes of ice-cold 50 mM Tris buffer (assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

US Patent
LigandPNGBDBM221042(US9284322, Table 6, Compound 8)
Affinity DataKi: >1.00E+4nMpH: 7.4Assay Description:Adult male rat cerebral cortices (Pel-Freez Biologicals, Rogers, Ark.) were homogenized (polytron) in 39 volumes of ice-cold 50 mM Tris buffer (assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
US Patent