Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 8418
TargetVascular endothelial growth factor receptor 2(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 1.27nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 3.08nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
US Patent

TargetVascular endothelial growth factor A(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 5.27nMAssay Description:Inhibition of VEGF-stimulated VEGFR-2 autophosphorylation in intact cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 8.5nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 8.79nMAssay Description:Inhibition of recombinant FGFR-2 tyrosine kinase using exogenous substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
US Patent

TargetAngiopoietin-1 receptor(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 10.1nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 10.6nMAssay Description:Inhibition of recombinant VEGFR-2 tyrosine kinase using exogenous substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
US Patent

LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 11.1nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 33.9nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 3(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 54.2nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 1(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 122nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
US Patent

TargetTyrosine-protein kinase Fyn(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 161nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
US Patent

TargetAurora kinase B(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 207nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 419nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 500nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 1.86E+3nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 2.64E+3nMAssay Description:Inhibition of recombinant PDGFR tyrosine kinase using exogenous substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor alpha(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 3.12E+3nMAssay Description:In Vitro Inhibition of Tyrosine Kinases using a 10-point Titration Curve.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 5.85E+3nMAssay Description:Inhibition of recombinant EGFR tyrosine kinase using exogenous substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
US Patent

TargetInsulin receptor(Human)
Panoptica

US Patent
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of recombinant IR tyrosine kinase using exogenous substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
US Patent