Compile Data Set for Download or QSAR
Report error Found 97 Enz. Inhib. hit(s) with all data for entry = 7629
TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50407517(CHEMBL1160723 | (-)ISOPROTERENOL | US9492405, 27)
Affinity DataIC50: 0.0500nMT: 2°CAssay Description:To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213098((R,R)-(-)-fenoterol | US9492405, (R,R)-1 | CHEMBL3...)
Affinity DataIC50: 0.140nMT: 2°CAssay Description:To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213099((R,R)-(-)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataIC50: 0.170nMT: 2°CAssay Description:To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213110((R,S)-(-)-5-{1-hydroxy-2-[1-methyl-2-(1-naphthyl)e...)
Affinity DataIC50: 1.19nMT: 2°CAssay Description:To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50348426(CHEMBL1800936 | US9492405, 48)
Affinity DataIC50: 1.44nMT: 2°CAssay Description:To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213115((R,R)-(-)-5-{1-hydroxy-2-[1-methyl-2-(1-naphthyl)e...)
Affinity DataIC50: 1.57nMT: 2°CAssay Description:To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50348428(CHEMBL1800961 | US9492405, 40)
Affinity DataIC50: 1.91nMT: 2°CAssay Description:To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213120((R,S)-(-)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataIC50: 2.01nMT: 2°CAssay Description:To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213097((S,R)-(+)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataIC50: 3.16nMT: 2°CAssay Description:To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50348430(CHEMBL1800963 | US9492405, 44)
Affinity DataIC50: 3.98nMT: 2°CAssay Description:To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50348431(CHEMBL1800934 | US9492405, 45)
Affinity DataIC50: 4.37nMT: 2°CAssay Description:To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213106((R,S)-(-)-fenoterol | US9492405, (R,S)-1 | CHEMBL2...)
Affinity DataIC50: 6.09nMT: 2°CAssay Description:To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213103((S,R)-(+)-fenoterol | US9492405, (S,R)-1 | CHEMBL2...)
Affinity DataIC50: 6.74nMT: 2°CAssay Description:To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213096((S,R)-(+)-5-{1-hydroxy-2-[1-methyl-2-(1-naphthyl)e...)
Affinity DataIC50: 14.8nMT: 2°CAssay Description:To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50348427(CHEMBL1800960 | US9492405, 49)
Affinity DataIC50: 17.9nMT: 2°CAssay Description:To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50348429(CHEMBL1800962 | US9492405, 41)
Affinity DataIC50: 72.6nMT: 2°CAssay Description:To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213114((S,S)-(+)-fenoterol | US9492405, (S,S)-1 | CHEMBL3...)
Affinity DataIC50: 184nMT: 2°CAssay Description:To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213115((R,R)-(-)-5-{1-hydroxy-2-[1-methyl-2-(1-naphthyl)e...)
Affinity DataIC50: 229nMT: 2°CAssay Description:To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213115((R,R)-(-)-5-{1-hydroxy-2-[1-methyl-2-(1-naphthyl)e...)
Affinity DataKd:  240nMpH: 7.7Assay Description:HEK 293 cells stability transfected with cDNA encoding human beta2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213115((R,R)-(-)-5-{1-hydroxy-2-[1-methyl-2-(1-naphthyl)e...)
Affinity DataKi:  241nM ΔG°:  -35.1kJ/molepH: 7.8 T: 2°CAssay Description:Beta1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213102((S,S)-(+)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataIC50: 337nMT: 2°CAssay Description:To measure beta2-AR mediated inhibition of mitogenesis, HEK-beta2-AR, 1321N1 or U87MG cells were seeded in a 96-well plate at approximately 5,000 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213110((R,S)-(-)-5-{1-hydroxy-2-[1-methyl-2-(1-naphthyl)e...)
Affinity DataKd:  339nMpH: 7.7Assay Description:HEK 293 cells stability transfected with cDNA encoding human beta2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213110((R,S)-(-)-5-{1-hydroxy-2-[1-methyl-2-(1-naphthyl)e...)
Affinity DataKi:  341nM ΔG°:  -34.3kJ/molepH: 7.8 T: 2°CAssay Description:Beta1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213098((R,R)-(-)-fenoterol | US9492405, (R,R)-1 | CHEMBL3...)
Affinity DataKi:  345nM ΔG°:  -34.3kJ/molepH: 7.8 T: 2°CAssay Description:Beta1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213098((R,R)-(-)-fenoterol | US9492405, (R,R)-1 | CHEMBL3...)
Affinity DataKd:  347nMpH: 7.7Assay Description:HEK 293 cells stability transfected with cDNA encoding human beta2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213099((R,R)-(-)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataKi:  474nM ΔG°:  -33.6kJ/molepH: 7.8 T: 2°CAssay Description:Beta1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213099((R,R)-(-)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataKd:  479nMpH: 7.7Assay Description:HEK 293 cells stability transfected with cDNA encoding human beta2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213096((S,R)-(+)-5-{1-hydroxy-2-[1-methyl-2-(1-naphthyl)e...)
Affinity DataKd:  1.78E+3nMpH: 7.7Assay Description:HEK 293 cells stability transfected with cDNA encoding human beta2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213096((S,R)-(+)-5-{1-hydroxy-2-[1-methyl-2-(1-naphthyl)e...)
Affinity DataKi:  1.78E+3nM ΔG°:  -30.5kJ/molepH: 7.8 T: 2°CAssay Description:Beta1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM206771((R,R)-4 | US9492405, (R,R)-4)
Affinity DataKd:  1.86E+3nMpH: 7.7Assay Description:HEK 293 cells stability transfected with cDNA encoding human beta2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM206771((R,R)-4 | US9492405, (R,R)-4)
Affinity DataKi:  1.86E+3nM ΔG°:  -30.4kJ/molepH: 7.8 T: 2°CAssay Description:Beta1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213120((R,S)-(-)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataKi:  1.93E+3nM ΔG°:  -30.3kJ/molepH: 7.8 T: 2°CAssay Description:Beta1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213120((R,S)-(-)-1-p-methoxyphenyl-2-(beta-3',5'-dihydrox...)
Affinity DataKd:  1.95E+3nMpH: 7.7Assay Description:HEK 293 cells stability transfected with cDNA encoding human beta2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213101((S,S)-(+)-5-{1-hydroxy-2-[1-methyl-2-(1-naphthyl)e...)
Affinity DataKd:  2.51E+3nMpH: 7.7Assay Description:HEK 293 cells stability transfected with cDNA encoding human beta2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213101((S,S)-(+)-5-{1-hydroxy-2-[1-methyl-2-(1-naphthyl)e...)
Affinity DataKi:  2.54E+3nM ΔG°:  -29.7kJ/molepH: 7.8 T: 2°CAssay Description:Beta1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213108((R,R)-(-)-5-{2-[2-(4-aminophenyl)-1-methylethylami...)
Affinity DataKi:  2.93E+3nM ΔG°:  -29.4kJ/molepH: 7.8 T: 2°CAssay Description:Beta1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213108((R,R)-(-)-5-{2-[2-(4-aminophenyl)-1-methylethylami...)
Affinity DataKd:  2.95E+3nMpH: 7.7Assay Description:HEK 293 cells stability transfected with cDNA encoding human beta2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-1 adrenergic receptor(Rat)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213115((R,R)-(-)-5-{1-hydroxy-2-[1-methyl-2-(1-naphthyl)e...)
Affinity DataKi:  3.35E+3nM ΔG°:  -29.0kJ/molepH: 7.8 T: 2°CAssay Description:Beta1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213106((R,S)-(-)-fenoterol | US9492405, (R,S)-1 | CHEMBL2...)
Affinity DataKi:  3.70E+3nM ΔG°:  -28.8kJ/molepH: 7.8 T: 2°CAssay Description:Beta1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213106((R,S)-(-)-fenoterol | US9492405, (R,S)-1 | CHEMBL2...)
Affinity DataKd:  3.72E+3nMpH: 7.7Assay Description:HEK 293 cells stability transfected with cDNA encoding human beta2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM206769( (S,R)-2 | US9492405, (S,R)-2)
Affinity DataKd:  5.25E+3nMpH: 7.7Assay Description:HEK 293 cells stability transfected with cDNA encoding human beta2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM206769( (S,R)-2 | US9492405, (S,R)-2)
Affinity DataKi:  5.27E+3nM ΔG°:  -28.0kJ/molepH: 7.8 T: 2°CAssay Description:Beta1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM206772((R,S)-4 | US9492405, (R,S)-4)
Affinity DataKd:  6.03E+3nMpH: 7.7Assay Description:HEK 293 cells stability transfected with cDNA encoding human beta2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM206772((R,S)-4 | US9492405, (R,S)-4)
Affinity DataKi:  6.04E+3nM ΔG°:  -27.7kJ/molepH: 7.8 T: 2°CAssay Description:Beta1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213112((R,S)-(-)-5-{2-[2-(4-aminophenyl)-1-methylethylami...)
Affinity DataKi:  7.94E+3nM ΔG°:  -27.1kJ/molepH: 7.8 T: 2°CAssay Description:Beta1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213112((R,S)-(-)-5-{2-[2-(4-aminophenyl)-1-methylethylami...)
Affinity DataKd:  7.94E+3nMpH: 7.7Assay Description:HEK 293 cells stability transfected with cDNA encoding human beta2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM206775((R,R)- 6 | US9492405, (R,R)-6)
Affinity DataKi:  9.28E+3nM ΔG°:  -26.7kJ/molepH: 7.8 T: 2°CAssay Description:Beta1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM206775((R,R)- 6 | US9492405, (R,R)-6)
Affinity DataKd:  9.33E+3nMpH: 7.7Assay Description:HEK 293 cells stability transfected with cDNA encoding human beta2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-1 adrenergic receptor(Rat)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM206775((R,R)- 6 | US9492405, (R,R)-6)
Affinity DataKi:  1.02E+4nM ΔG°:  -26.5kJ/molepH: 7.8 T: 2°CAssay Description:Beta1-AR binding was done on rat cortical membrane following a previously described procedure (Beer et al., Biochem. Pharmacol. 37: 1145-1151, 1988)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50213103((S,R)-(+)-fenoterol | US9492405, (S,R)-1 | CHEMBL2...)
Affinity DataKd:  1.02E+4nMpH: 7.7Assay Description:HEK 293 cells stability transfected with cDNA encoding human beta2-AR (provided by Dr. Brian Kobilka, Stanford Medical Center, Palo Alto, Calif.) wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2016
Entry Details
US Patent

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