Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) with all data for entry = 774
TargetSphingosine 1-phosphate receptor 1(Human)
Allergan

US Patent
LigandPNGBDBM290122(US9572792, Compound 62 | (4R)-4-amino-5-[(4-{[(7-m...)
Affinity DataEC50:  3.10nMpH: 7.4Assay Description:The S1P1 activity of the compounds according to the invention, were tested using the GTP γ35S binding assay. The compounds were assessed for the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Allergan

US Patent
LigandPNGBDBM290123(US9572792, Compound 38 | N-[4-(aminosulfonyl)-2-br...)
Affinity DataEC50:  3.5nMpH: 7.4Assay Description:The S1P1 activity of the compounds according to the invention, were tested using the GTP γ35S binding assay. The compounds were assessed for the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Allergan

US Patent
LigandPNGBDBM290124(US9572792, Compound 49 | N-{4-[(ethylsulfonyl)amin...)
Affinity DataEC50:  14.3nMpH: 7.4Assay Description:The S1P1 activity of the compounds according to the invention, were tested using the GTP γ35S binding assay. The compounds were assessed for the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Allergan

US Patent
LigandPNGBDBM290032(US9572792, Compound 6 | N-(3-bromopyridin-4-yl)-7-...)
Affinity DataEC50:  19nMpH: 7.4Assay Description:The S1P1 activity of the compounds according to the invention, were tested using the GTP γ35S binding assay. The compounds were assessed for the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Allergan

US Patent
LigandPNGBDBM290121(US9572792, Compound 5 | N-(2-bromophenyl)-7-methox...)
Affinity DataEC50:  26.4nMpH: 7.4Assay Description:The S1P1 activity of the compounds according to the invention, were tested using the GTP γ35S binding assay. The compounds were assessed for the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent