Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 1222
TargetBeta-secretase 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM312923(US9605006, 22 | 5-But-2-ynyloxy-pyrazine-2-carboxy...)
Affinity DataIC50: 0.200nMAssay Description:The Abeta 40 AlphaLISA Assay can be used. The HEK293 APP cells were seeded in 96 well Microtiter plates in cell culture medium (Iscove's, plus 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM312921(US9605006, 20 | 3-Chloro-5-cyano-pyridine-2-carbox...)
Affinity DataIC50: 1nMAssay Description:The Abeta 40 AlphaLISA Assay can be used. The HEK293 APP cells were seeded in 96 well Microtiter plates in cell culture medium (Iscove's, plus 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM312925(US9605006, 23 | 5-Fluoro-3-methyl-pyridine-2-carbo...)
Affinity DataIC50: 1.5nMAssay Description:The Abeta 40 AlphaLISA Assay can be used. The HEK293 APP cells were seeded in 96 well Microtiter plates in cell culture medium (Iscove's, plus 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM312926(US9605006, 25 | N-(3-((8R)-6-amino-3,3-difluoro-8-...)
Affinity DataIC50: 2nMAssay Description:The Abeta 40 AlphaLISA Assay can be used. The HEK293 APP cells were seeded in 96 well Microtiter plates in cell culture medium (Iscove's, plus 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM312913(US9605006, 2)
Affinity DataIC50: 2nMAssay Description:The Abeta 40 AlphaLISA Assay can be used. The HEK293 APP cells were seeded in 96 well Microtiter plates in cell culture medium (Iscove's, plus 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM312918(US9605006, 17 | (9R,11R)-7-Amino-9-(2-fluoro-5-(3-...)
Affinity DataIC50: 9nMAssay Description:The Abeta 40 AlphaLISA Assay can be used. The HEK293 APP cells were seeded in 96 well Microtiter plates in cell culture medium (Iscove's, plus 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM312922(US9605006, 21 | 5-(2,2,2-Trifluoro-ethoxy)-pyridin...)
Affinity DataIC50: 10nMAssay Description:The Abeta 40 AlphaLISA Assay can be used. The HEK293 APP cells were seeded in 96 well Microtiter plates in cell culture medium (Iscove's, plus 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM312914(US9605006, 13 | (9R,11R)-7-Amino-9-(5-(3-(5-chloro...)
Affinity DataIC50: 12nMAssay Description:The Abeta 40 AlphaLISA Assay can be used. The HEK293 APP cells were seeded in 96 well Microtiter plates in cell culture medium (Iscove's, plus 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM312920(US9605006, 19 | (9R,11R)-7-Amino-9-(5-(3-(5-(2,2-d...)
Affinity DataIC50: 14nMAssay Description:The Abeta 40 AlphaLISA Assay can be used. The HEK293 APP cells were seeded in 96 well Microtiter plates in cell culture medium (Iscove's, plus 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM312917(US9605006, 16 | 4-43-49R,11R)-7-Amino-9-methyl-11-...)
Affinity DataIC50: 21nMAssay Description:The Abeta 40 AlphaLISA Assay can be used. The HEK293 APP cells were seeded in 96 well Microtiter plates in cell culture medium (Iscove's, plus 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM312912(US9605006, 1)
Affinity DataIC50: 45nMAssay Description:The Abeta 40 AlphaLISA Assay can be used. The HEK293 APP cells were seeded in 96 well Microtiter plates in cell culture medium (Iscove's, plus 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM312916(US9605006, 15 | 6-(4-(3-((9R,11S)-7-Amino-9-methyl...)
Affinity DataIC50: 95nMAssay Description:The Abeta 40 AlphaLISA Assay can be used. The HEK293 APP cells were seeded in 96 well Microtiter plates in cell culture medium (Iscove's, plus 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM312915(US9605006, 14 | (9R,11S)-7-Amino-9-(5-(3-(5-chloro...)
Affinity DataIC50: 95nMAssay Description:The Abeta 40 AlphaLISA Assay can be used. The HEK293 APP cells were seeded in 96 well Microtiter plates in cell culture medium (Iscove's, plus 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM312919(US9605006, 18 | (9R,118)-7-Amino-9-(2-fluoro-5-(3-...)
Affinity DataIC50: 694nMAssay Description:The Abeta 40 AlphaLISA Assay can be used. The HEK293 APP cells were seeded in 96 well Microtiter plates in cell culture medium (Iscove's, plus 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM312910(US9605006, A20a2)
Affinity DataIC50: 1.04E+3nMAssay Description:The Abeta 40 AlphaLISA Assay can be used. The HEK293 APP cells were seeded in 96 well Microtiter plates in cell culture medium (Iscove's, plus 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent