Compile Data Set for Download or QSAR
Report error Found 228 Enz. Inhib. hit(s) with all data for entry = 2149
TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356152BDBM356152(US9815846, Compound 152 | 2-fluoro-5-(1-methyl-1H-...)
Affinity DataIC50: 0.0690nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356096BDBM356096(US9815846, Compound 96 | N-(2-((2,5-dioxoimidazoli...)
Affinity DataIC50: 0.0830nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356095BDBM356095(US9815846, Compound 95)
Affinity DataIC50: 0.110nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356218BDBM356218(US9815846, Compound 218)
Affinity DataIC50: 0.140nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356196BDBM356196(US9815846, Compound 196)
Affinity DataIC50: 0.190nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356058BDBM356058(US9815846, Compound 58 | 2-fluoro-N-(6-((2- methox...)
Affinity DataIC50: 0.190nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356222BDBM356222(US9815846, Compound 222 | 2-fluoro-5-(1-methyl-1H-...)
Affinity DataIC50: 0.220nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356098BDBM356098(US9815846, Compound 98 | N-(6-((2,5-dioxoimidazoli...)
Affinity DataIC50: 0.220nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356059BDBM356059(US9815846, Compound 59 | 2-fluoro-5-(1-methyl-1H- ...)
Affinity DataIC50: 0.230nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356227BDBM356227(US9815846, Compound 227 | 2-fluoro-5-(1-methyl-1H-...)
Affinity DataIC50: 0.240nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356097BDBM356097(US9815846, Compound 97 | N-(2-((2,4-dioxooxazolidi...)
Affinity DataIC50: 0.25nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356129BDBM356129(US9815846, Compound 129)
Affinity DataIC50: 0.25nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356172BDBM356172(US9815846, Compound 172 | 2-fluoro-N-(5-(2- hydrox...)
Affinity DataIC50: 0.260nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356144BDBM356144(US9815846, Compound 144)
Affinity DataIC50: 0.260nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356178BDBM356178(US9815846, Compound 178 | N-(5-(1-aminoethyl)-6'-p...)
Affinity DataIC50: 0.290nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356219BDBM356219(US9815846, Compound 219 | 2-fluoro-5-(1-methyl-1H-...)
Affinity DataIC50: 0.320nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356226BDBM356226(US9815846, Compound 226 | N-(2-((2,4-dioxo-3,4- di...)
Affinity DataIC50: 0.350nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356215BDBM356215(US9815846, Compound 215)
Affinity DataIC50: 0.360nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356161BDBM356161(US9815846, Compound 161 | 2-fluoro-5-(1-methyl-1H-...)
Affinity DataIC50: 0.380nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356068BDBM356068(US9815846, Compound 68 | 2-fluoro-5-(1-methyl-1H- ...)
Affinity DataIC50: 0.400nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356064BDBM356064(US9815846, Compound 64 | 2-fluoro-N-(2-((2- methox...)
Affinity DataIC50: 0.440nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356056BDBM356056(US9815846, Compound 56 | (S)-2-fluoro-N-(6-((2- hy...)
Affinity DataIC50: 0.450nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356080BDBM356080(US9815846, Compound 80)
Affinity DataIC50: 0.490nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356189BDBM356189(US9815846, Compound 189)
Affinity DataIC50: 0.510nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356164BDBM356164(US9815846, Compound 164)
Affinity DataIC50: 0.510nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356070BDBM356070(US9815846, Compound 70 | 2-fluoro-5-(1-methyl-1H- ...)
Affinity DataIC50: 0.530nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356105BDBM356105(US9815846, Compound 105 | N-(2-(2-(ethylamino)-2- ...)
Affinity DataIC50: 0.530nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356128BDBM356128(US9815846, Compound 128)
Affinity DataIC50: 0.540nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356151BDBM356151(US9815846, Compound 151 | N-(6-acetyl-2-phenyl-5,6...)
Affinity DataIC50: 0.540nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356198BDBM356198(US9815846, Compound 198)
Affinity DataIC50: 0.570nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356135BDBM356135(US9815846, Compound 135)
Affinity DataIC50: 0.570nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356072BDBM356072(US9815846, Compound 72 | (S)-2-fluoro-N-(6-((2-hyd...)
Affinity DataIC50: 0.570nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356085BDBM356085(US9815846, Compound 85 | (S)-5-(2-fluoro-5-(1-meth...)
Affinity DataIC50: 0.580nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356099BDBM356099(US9815846, Compound 99)
Affinity DataIC50: 0.590nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356169BDBM356169(US9815846, Compound 169 | 2-(5-(2-fluoro-5-(pyrimi...)
Affinity DataIC50: 0.590nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356061BDBM356061(US9815846, Compound 62 | (S or R)-N-(6-((2,3- dihy...)
Affinity DataIC50: 0.640nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356228BDBM356228(US9815846, Compound 228 | (R or S)-2-fluoro-N-(2-(...)
Affinity DataIC50: 0.660nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356187BDBM356187(US9815846, Compound 187)
Affinity DataIC50: 0.680nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356168BDBM356168(US9815846, Compound 168 | 2-fluoro-N-(5-(hydroxyme...)
Affinity DataIC50: 0.680nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356034BDBM356034(US9815846, Compound 34 | N-(2-(cyanomethyl)-4- phe...)
Affinity DataIC50: 0.690nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356154BDBM356154(US9815846, Compound 154 | 3-(2-fluoro-5-(1-methyl-...)
Affinity DataIC50: 0.760nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356104BDBM356104(US9815846, Compound 104 | 2-fluoro-5-(1-methyl-1H-...)
Affinity DataIC50: 0.760nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356061BDBM356061(US9815846, Compound 62 | (S or R)-N-(6-((2,3- dihy...)
Affinity DataIC50: 0.790nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356102BDBM356102(US9815846, Compound 102)
Affinity DataIC50: 0.790nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356076BDBM356076(US9815846, Compound 76)
Affinity DataIC50: 0.840nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356077BDBM356077(US9815846, Compound 77 | 2-fluoro-5-(1-methyl-1H- ...)
Affinity DataIC50: 1nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356027BDBM356027(US9815846, Compound 27 | 2-fluoro-N-(2-methyl-4- p...)
Affinity DataIC50: 1nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356156BDBM356156(US9815846, Compound 156 | N-(6-glycyl-2-phenyl-5,6...)
Affinity DataIC50: 1nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356220BDBM356220(US9815846, Compound 220 | 2-fluoro-5-(1-methyl-1H-...)
Affinity DataIC50: 1nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 356179BDBM356179(US9815846, Compound 179)
Affinity DataIC50: 1nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

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