Compile Data Set for Download or QSAR
Report error Found 103 Enz. Inhib. hit(s) with all data for entry = 2407
TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364467BDBM364467(US9862707, Example 41)
Affinity DataIC50: 0.160nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364459BDBM364459(US9862707, Example 33 | US9862707, Example 34 | (R...)
Affinity DataIC50: 0.25nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364459BDBM364459(US9862707, Example 33 | US9862707, Example 34 | (R...)
Affinity DataIC50: 0.480nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364499BDBM364499(US9862707, Example 74)
Affinity DataIC50: 0.570nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364512BDBM364512(US9862707, Example 87 | 3-({[2-fluoro-5-(1-methyl-...)
Affinity DataIC50: 0.630nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364520BDBM364520(US9862707, Example 95)
Affinity DataIC50: 0.640nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364431BDBM364431(US9862707, Example 5 | 2-fluoro-5-(1-methyl-1H-pyr...)
Affinity DataIC50: 0.660nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364447BDBM364447(US9862707, Example 21 | US9862707, Example 22)
Affinity DataIC50: 0.690nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364480BDBM364480(US9862707, Example 54 | US9862707, Example 55 | (R...)
Affinity DataIC50: 0.820nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364436BDBM364436(US9862707, Example 10)
Affinity DataIC50: 0.840nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364524BDBM364524(US9862707, Example 99 | N-(7-((2,5-dioxoimidazolid...)
Affinity DataIC50: 0.880nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364455BDBM364455(US9862707, Example 29 | US9862707, Example 30 | (R...)
Affinity DataIC50: 1.10nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364440BDBM364440(US9862707, Example 14 | 2-fluoro-N-[6-(hydroxymeth...)
Affinity DataIC50: 1.20nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364447BDBM364447(US9862707, Example 21 | US9862707, Example 22)
Affinity DataIC50: 1.20nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364502BDBM364502(US9862707, Example 77)
Affinity DataIC50: 1.30nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364476BDBM364476(US9862707, Example 50)
Affinity DataIC50: 1.60nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364472BDBM364472(US9862707, Example 46 | 2-chloro-N-[6-(1-hydroxy-1...)
Affinity DataIC50: 1.70nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364461BDBM364461(US9862707, Example 35 | (R or S)-2-chloro-N-[6-(1-...)
Affinity DataIC50: 1.70nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364455BDBM364455(US9862707, Example 29 | US9862707, Example 30 | (R...)
Affinity DataIC50: 1.80nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364526BDBM364526(US9862707, Example 101)
Affinity DataIC50: 1.80nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364496BDBM364496(US9862707, Example 71 | N-[6-(aminomethyl)-2-pheny...)
Affinity DataIC50: 1.80nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364444BDBM364444(US9862707, Example 18 | 2-fluoro-N-[5-(hydroxymeth...)
Affinity DataIC50: 1.90nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364445BDBM364445(US9862707, Example 19 | US9862707, Example 20)
Affinity DataIC50: 1.90nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364486BDBM364486(US9862707, Example 60)
Affinity DataIC50: 2.20nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364461BDBM364461(US9862707, Example 35 | (R or S)-2-chloro-N-[6-(1-...)
Affinity DataIC50: 2.40nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364449BDBM364449(US9862707, Example 23 | (R or S)-N-[5-(1-hydroxyet...)
Affinity DataIC50: 2.40nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364438BDBM364438(US9862707, Example 12 | 2-fluoro-N-[5-(hydroxymeth...)
Affinity DataIC50: 2.60nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364473BDBM364473(US9862707, Example 47 | 2-fluoro-N-[6-(1-hydroxy-1...)
Affinity DataIC50: 2.60nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364509BDBM364509(US9862707, Example 84 | 3-({[2-fluoro-5-pyridin-2-...)
Affinity DataIC50: 2.60nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364470BDBM364470(US9862707, Example 44)
Affinity DataIC50: 2.70nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364507BDBM364507(US9862707, Example 82 | 3-({[3-(1-methyl-1H-pyrazo...)
Affinity DataIC50: 2.70nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364525BDBM364525(US9862707, Example 100)
Affinity DataIC50: 2.70nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364511BDBM364511(US9862707, Example 86 | 3-({[3-(1-methyl-1H-pyrazo...)
Affinity DataIC50: 2.80nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364478BDBM364478(US9862707, Example 52 | US9862707, Example 53)
Affinity DataIC50: 2.80nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364482BDBM364482(US9862707, Example 56 | US9862707, Example 57 | (R...)
Affinity DataIC50: 2.80nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364506BDBM364506(US9862707, Example 81 | 3-({[2-fluoro-5-pyridin-2-...)
Affinity DataIC50: 2.90nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364445BDBM364445(US9862707, Example 19 | US9862707, Example 20)
Affinity DataIC50: 2.90nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364487BDBM364487(US9862707, Example 61 | 2-fluoro-N-[5-(2-hydroxyet...)
Affinity DataIC50: 3.10nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364498BDBM364498(US9862707, Example 73)
Affinity DataIC50: 3.10nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364510BDBM364510(US9862707, Example 85 | 3-({[2-chloro-5-pyridin-2-...)
Affinity DataIC50: 3.30nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364503BDBM364503(US9862707, Example 78 | 3-({[2-fluoro-5-(1H-pyrazo...)
Affinity DataIC50: 3.60nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364449BDBM364449(US9862707, Example 23 | (R or S)-N-[5-(1-hydroxyet...)
Affinity DataIC50: 3.70nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364439BDBM364439(US9862707, Example 13 | 2-fluoro-N-[6-(hydroxymeth...)
Affinity DataIC50: 3.80nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364466BDBM364466(US9862707, Example 40)
Affinity DataIC50: 3.90nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364519BDBM364519(US9862707, Example 94)
Affinity DataIC50: 4.40nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364463BDBM364463(US9862707, Example 37 | US9862707, Example 38 | (R...)
Affinity DataIC50: 4.40nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364474BDBM364474(US9862707, Example 48 | US9862707, Example 49 | N-...)
Affinity DataIC50: 4.60nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364468BDBM364468(US9862707, Example 42)
Affinity DataIC50: 4.60nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364484BDBM364484(US9862707, Example 58 | (R or S)-N-[5-(2,2-difluor...)
Affinity DataIC50: 4.90nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 364488BDBM364488(US9862707, Example 62 | US9862707, Example 63)
Affinity DataIC50: 4.90nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

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