Compile Data Set for Download or QSAR
Report error Found 1144 Enz. Inhib. hit(s) with all data for entry = 2450
TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366982BDBM366982(4,4,4-trifluoro-1-[4-[2- [4-[4-(4-pyridyl)-1,4- di...)
Affinity DataKi:  0.0800nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366699BDBM366699(US9873709, Example 1-296 | 3-[[1-[2-[4-[[8-[4-(4- ...)
Affinity DataKi:  0.130nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366678BDBM366678(US9873709, Example 1-275 | [4-[[8-[4-(4- chlorophe...)
Affinity DataKi:  0.140nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366686BDBM366686(US9873709, Example 1-283 | [4-[[8-[4-(4- chlorophe...)
Affinity DataKi:  0.150nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366677BDBM366677(US9873709, Example 1-274 | [4-[[8-[4-(4- chlorophe...)
Affinity DataKi:  0.170nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366686BDBM366686(US9873709, Example 1-283 | [4-[[8-[4-(4- chlorophe...)
Affinity DataKi:  0.180nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366694BDBM366694(US9873709, Example 1-291 | 2-[4-[[8-[4-(4- chlorop...)
Affinity DataKi:  0.180nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366693BDBM366693(US9873709, Example 1-290 | formic acid; methyl 3- ...)
Affinity DataKi:  0.180nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 367096BDBM367096(4,4,4-trifluoro-1-[4-[2- [4-[4-(3- pyridyl)piperaz...)
Affinity DataKi:  0.180nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366862BDBM366862(4,4,4-trifluoro-1-[4-[2- [4-[4-(2- pyridyl)piperid...)
Affinity DataKi:  0.200nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366677BDBM366677(US9873709, Example 1-274 | [4-[[8-[4-(4- chlorophe...)
Affinity DataKi:  0.200nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366448BDBM366448(4-[[8-[4- (cyanomethyl)-4- phenyl-1-piperidyl]- [1...)
Affinity DataKi:  0.200nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366699BDBM366699(US9873709, Example 1-296 | 3-[[1-[2-[4-[[8-[4-(4- ...)
Affinity DataKi:  0.200nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366678BDBM366678(US9873709, Example 1-275 | [4-[[8-[4-(4- chlorophe...)
Affinity DataKi:  0.210nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366685BDBM366685(US9873709, Example 1-282 | [4-[[8-[4-(4- chlorophe...)
Affinity DataKi:  0.210nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366803BDBM366803(1-[4-[2-[4-[4- (dimethylamino) piperidine-1- carbo...)
Affinity DataKi:  0.210nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366921BDBM366921(4,4,4-trifluoro-1-[4-[2- [4-[4-(5-methyl-2- pyridy...)
Affinity DataKi:  0.210nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 367041BDBM367041(4,4,4-trifluoro-1-[4-[2- [4-[3-(4- pyridyl)pyrroli...)
Affinity DataKi:  0.220nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366991BDBM366991(4-[[8-[1-(3- cyanopropanoyl)-3,6- dihydro-2H-pyrid...)
Affinity DataKi:  0.220nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366918BDBM366918(N-methyl-N-[2-(3- pyridyl)ethyl]-4-[[8- [1-(4,4,4-...)
Affinity DataKi:  0.230nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366981BDBM366981(4,4,4-trifluoro-1-[4-[2- [4-[4-(3- pyridylmethyl) ...)
Affinity DataKi:  0.230nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366681BDBM366681(US9873709, Example 1-278 | 4-[[8-[4-(4- chlorophen...)
Affinity DataKi:  0.230nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366683BDBM366683(US9873709, Example 1-280 | 4-[[8-[4-(4- chlorophen...)
Affinity DataKi:  0.230nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 367105BDBM367105(4,4,4-trifluoro-1-[4-[2- [4-[4-(2- pyridylmethyl) ...)
Affinity DataKi:  0.240nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366680BDBM366680(US9873709, Example 1-277 | 4-[[8-[4-(4- chlorophen...)
Affinity DataKi:  0.240nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 367095BDBM367095(4,4,4-trifluoro-1-[4-[2- [4-[4-(3- pyridylmethyl) ...)
Affinity DataKi:  0.240nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366670BDBM366670(US9873709, Example 1-267 | 4-[[8-[4-[4- (difluorom...)
Affinity DataKi:  0.25nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366682BDBM366682(US9873709, Example 1-279 | [4-[[8-[4-(4- chlorophe...)
Affinity DataKi:  0.25nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366713BDBM366713(US9873709, Example 2-7 | cyanomethyl 4-[2-[4- [met...)
Affinity DataKi:  0.25nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 367169BDBM367169(4,4,4-trifluoro-1-[4-[2- [4-[4-(6-methyl-2- pyridy...)
Affinity DataKi:  0.260nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366984BDBM366984(4,4,4-trifluoro-1-[4-[2- [4-[2-(3- pyridyl)piperid...)
Affinity DataKi:  0.260nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366689BDBM366689(US9873709, Example 1-286 | 4-[[8-[4-(4- chlorophen...)
Affinity DataKi:  0.260nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366692BDBM366692(US9873709, Example 1-289 | 2-[4-[[8-[4-(4- chlorop...)
Affinity DataKi:  0.260nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366969BDBM366969(4,4,4-trifluoro-1-[4-[2- [4-[2-(2- pyridylmethyl) ...)
Affinity DataKi:  0.260nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 367106BDBM367106(4,4,4-trifluoro-1-[4-[2- [4-[3-(3- pyridylmethyl) ...)
Affinity DataKi:  0.270nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366437BDBM366437(4-[[8-[4-(2-amino-2- oxo-ethyl)-4-phenyl-1- piperi...)
Affinity DataKi:  0.270nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366863BDBM366863(1-[4-[2-[4-[4-(2,6- dimethylmorpholin-4- yl)piperi...)
Affinity DataKi:  0.270nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366689BDBM366689(US9873709, Example 1-286 | 4-[[8-[4-(4- chlorophen...)
Affinity DataKi:  0.270nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366925BDBM366925(N-ethyl-N-(4- pyridylmethyl)-4-[[8- [1-(4,4,4- tri...)
Affinity DataKi:  0.280nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 367108BDBM367108(N-methyl-N-(4- pyridylmethyl)-4-[[8- [1-(4,4,4- tr...)
Affinity DataKi:  0.280nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366869BDBM366869(N-methyl-N-(1- methyl-4-piperidyl)-4- [[8-[1-(3,3,...)
Affinity DataKi:  0.290nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 367163BDBM367163(4,4,4-trifluoro-1-[4-[2- [4-[4-(2-imidazol-1- ylet...)
Affinity DataKi:  0.290nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366916BDBM366916(4,4,4-trifluoro-1-[4-[2- [4-(4- morpholinopiperidi...)
Affinity DataKi:  0.290nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 367175BDBM367175(4,4,4-trifluoro-1-[4-[2- [4-[4-(2- morpholinoethyl...)
Affinity DataKi:  0.290nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 367103BDBM367103(N-methyl-N-(3- pyridylmethyl)-4-[[8- [1-(4,4,4- tr...)
Affinity DataKi:  0.290nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366693BDBM366693(US9873709, Example 1-290 | formic acid; methyl 3- ...)
Affinity DataKi:  0.300nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 367162BDBM367162(4,4,4-trifluoro-1-[4-[2- [4-[4-(3-methyl-1- piperi...)
Affinity DataKi:  0.300nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366859BDBM366859(4,4,4-trifluoro-1-[4-[2- [4-[4-(2- hydroxyethyl) p...)
Affinity DataKi:  0.300nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 366683BDBM366683(US9873709, Example 1-280 | 4-[[8-[4-(4- chlorophen...)
Affinity DataKi:  0.300nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 367043BDBM367043(4,4,4-trifluoro-1-[4-[2- [4-[4-(tetrahydrofuran- 2...)
Affinity DataKi:  0.310nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

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