Compile Data Set for Download or QSAR
Report error Found 200 Enz. Inhib. hit(s) with all data for entry = 2806
TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380805BDBM380805(8-(1-Methyl-1H-indazol-6-yl)-3,4- dihydro-1H-pyran...)
Affinity DataIC50: 5.70nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380826BDBM380826(US9890171, 45 | 8-Isoquinolin-6-yl-3,4-dihydro-1H-...)
Affinity DataIC50: 5.80nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380803BDBM380803(2-Chloro-4-(4-hydroxy-3,4-dihydro- 1H-pyrano[4,3-c...)
Affinity DataIC50: 6.10nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380923BDBM380923(8-(3-Chloro-1H-indazol-6-yl)-3,4- dihydro-1H-pyran...)
Affinity DataIC50: 6.70nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380811BDBM380811(8-(3-Fluoro-1-methyl-1H-indazol-6- yl)-3,4-dihydro...)
Affinity DataIC50: 7.60nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380811BDBM380811(8-(3-Fluoro-1-methyl-1H-indazol-6- yl)-3,4-dihydro...)
Affinity DataIC50: 7.80nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380965BDBM380965(US9890171, 170 | 4-Methyl-8-(1-methyl-1H-indazol- ...)
Affinity DataIC50: 7.80nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380812BDBM380812(8-(1-methylindazol-6-yl)spiro[1,4- dihydropyrano[4...)
Affinity DataIC50: 8nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380892BDBM380892(8-(4-Fluoro-1-methyl-1H-indazol-6- yl)-3,4-dihydro...)
Affinity DataIC50: 8.10nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380886BDBM380886(8-(3-Methyl-benzo[d]isoxazol-5-yl)- 3,4-dihydro-1H...)
Affinity DataIC50: 8.5nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380825BDBM380825(8-(1-Methyl-1H-indazol-6-yl)-3,4- dihydro-1H-pyran...)
Affinity DataIC50: 8.5nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380818BDBM380818(US9890171, 35 | 8-Quinolin-6-yl-3,4-dihydro-1H- py...)
Affinity DataIC50: 9.70nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380800BDBM380800(US9890171, 6 | 4-(4-Hydroxy-3,4-dihydro-1H- pyrano...)
Affinity DataIC50: 9.80nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380899BDBM380899(5-(4-Hydroxy-3,4-dihydro-1H- pyrano[4,3-c]pyridin-...)
Affinity DataIC50: 10nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380886BDBM380886(8-(3-Methyl-benzo[d]isoxazol-5-yl)- 3,4-dihydro-1H...)
Affinity DataIC50: 10.1nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380967BDBM380967(8-(3-Fluoro-1-methyl-1H-indazol-6- yl)-4-methyl-3,...)
Affinity DataIC50: 10.2nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380924BDBM380924(N-[8-(3-Chloro-1H-indazol-6-yl)-3,4- dihydro-1H-py...)
Affinity DataIC50: 11.2nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380888BDBM380888(8-(4-fluoro-1-methyl-indazol-6- yl)spiro[1,4-dihyd...)
Affinity DataIC50: 11.5nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380821BDBM380821(8-(2,3-Dihydro-benzo[1,4]dioxin-6- yl)-3,4-dihydro...)
Affinity DataIC50: 12nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380812BDBM380812(8-(1-methylindazol-6-yl)spiro[1,4- dihydropyrano[4...)
Affinity DataIC50: 12.5nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380913BDBM380913(6-(4-Hydroxy-3,4-dihydro-1H- pyrano[4,3-c]pyridin-...)
Affinity DataIC50: 12.5nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380983BDBM380983(US9890171, 189 | 8-(1-Methyl-4,5-dihydro-1H-indazo...)
Affinity DataIC50: 12.9nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380954BDBM380954(Ethanesulfonic acid [8-(2-oxo-2H- chromen-6-yl)-3,...)
Affinity DataIC50: 13nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380906BDBM380906(7-(4-Hydroxy-3,4-dihydro-1H- pyrano[4,3-c]pyridin-...)
Affinity DataIC50: 13nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380971BDBM380971(US9890171, 176 | 8-(4-Fluoro-1-methyl-1H-indazol-6...)
Affinity DataIC50: 13.4nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380965BDBM380965(US9890171, 170 | 4-Methyl-8-(1-methyl-1H-indazol- ...)
Affinity DataIC50: 13.9nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380982BDBM380982(US9890171, 192 | 4-(4-Hydroxy-3,4-dihydro-1H- pyra...)
Affinity DataIC50: 14nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380921BDBM380921(6-(4-Hydroxy-3,4-dihydro-1H- pyrano[4,3-c]pyridin-...)
Affinity DataIC50: 14nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380909BDBM380909(6-(4-Hydroxy-3,4-dihydro-1H- pyrano[4,3-c]pyridin-...)
Affinity DataIC50: 14.5nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380973BDBM380973(6-(4-Hydroxy-4-methyl-3,4-dihydro- 1H-pyrano[4,3-c...)
Affinity DataIC50: 15nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380810BDBM380810(US9890171, 188 | 8-(3-Methyl-3H-benzotriazol-5-yl)...)
Affinity DataIC50: 15.7nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380864BDBM380864(Ethanesulfonic acid [8-(3-fluoro-1- methyl-1H-inda...)
Affinity DataIC50: 15.9nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380918BDBM380918(US9890171, 123 | 7-(4-Hydroxy-3,4-dihydro-1H- pyra...)
Affinity DataIC50: 16.3nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380817BDBM380817(US9890171, 34 | 8-(1H-Indol-6-yl)-3,4-dihydro-1H- ...)
Affinity DataIC50: 17.3nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380945BDBM380945(8-(4-Fluoro-1-methyl-1H-indazol-6- yl)-3,4-dihydro...)
Affinity DataIC50: 17.3nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380827BDBM380827(US9890171, 48 | 8-(1H-Indol-5-yl)-3,4-dihydro-1H- ...)
Affinity DataIC50: 17.4nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380946BDBM380946(N-[8-(4-Fluoro-1-methyl-1H-indazol- 6-yl)-3,4-dihy...)
Affinity DataIC50: 17.4nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380819BDBM380819(US9890171, 36 | 8-(1-Methyl-1H-indazol-5-yl)-3,4- ...)
Affinity DataIC50: 17.5nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380872BDBM380872(N-[8-(1-Methyl-1H-indazol-6-yl)-3,4- dihydro-1H-py...)
Affinity DataIC50: 17.9nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380993BDBM380993(US9890171, 198 | 8-(3-methylbenzotriazol-5- yl)spi...)
Affinity DataIC50: 18nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380981BDBM380981(Dimethyl-[8-(1-methyl-1H-indazol- 6-yl)-3,4-dihydr...)
Affinity DataIC50: 18nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380910BDBM380910(8-(3-methyl-1,2-benzoxazol-5- yl)spiro[1,4-dihydro...)
Affinity DataIC50: 18.8nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380993BDBM380993(US9890171, 198 | 8-(3-methylbenzotriazol-5- yl)spi...)
Affinity DataIC50: 19nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380967BDBM380967(8-(3-Fluoro-1-methyl-1H-indazol-6- yl)-4-methyl-3,...)
Affinity DataIC50: 19.1nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380814BDBM380814(8-(5-Fluoro-1-methyl-1H-indazol-6- yl)-3,4-dihydro...)
Affinity DataIC50: 20.1nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380810BDBM380810(US9890171, 188 | 8-(3-Methyl-3H-benzotriazol-5-yl)...)
Affinity DataIC50: 21nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380806BDBM380806(US9890171, 12 | 8-(3-Methyl-1H-indazol-5-yl)-3,4- ...)
Affinity DataIC50: 21nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380971BDBM380971(US9890171, 176 | 8-(4-Fluoro-1-methyl-1H-indazol-6...)
Affinity DataIC50: 21.6nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380995BDBM380995(US9890171, 200 | 8-(4,4-Difluoro-isochroman-7-yl)-...)
Affinity DataIC50: 22nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 380824BDBM380824(8-(3,4-Dihydro-2H- benzo[b][1,4]dioxepin-7-yl)-3,4...)
Affinity DataIC50: 22nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

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