Compile Data Set for Download or QSAR
Report error Found 114 Enz. Inhib. hit(s) with all data for entry = 2702
TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376040BDBM376040(US9914736, Compound 36 | 2-chloro-5-(1-methyl-1H- ...)
Affinity DataIC50: 0.370nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376080BDBM376080(US9914736, Compound 76 | 5-({[2-fluoro-5-(1-methyl...)
Affinity DataIC50: 0.390nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376106BDBM376106(US9914736, Compound 102 | 2-fluoro-N-(1-(4- fluoro...)
Affinity DataIC50: 0.400nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376085BDBM376085(US9914736, Compound 81 | N-[3-(4-carbamoylphenyl)-...)
Affinity DataIC50: 0.760nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376063BDBM376063(US9914736, Compound 59 | US9914736, Compound 80 | ...)
Affinity DataIC50: 0.780nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376052BDBM376052(US9914736, Compound 48 | 2-chloro-N-(3,5'-dimethyl...)
Affinity DataIC50: 0.820nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376009BDBM376009(US9914736, Compound 5 | N-(1$#8243;,5-dimethyl-1H,...)
Affinity DataIC50: 0.850nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376109BDBM376109(US9914736, Compound 105 | 2-fluoro-N-(1-(4- fluoro...)
Affinity DataIC50: 0.980nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376111BDBM376111(US9914736, Compound 107 | (S or R)-2-fluoro-N-(1-(...)
Affinity DataIC50: 1nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376089BDBM376089(US9914736, Compound 85 | 2-fluoro-N-(1-(4- fluorop...)
Affinity DataIC50: 1.20nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376096BDBM376096(US9914736, Compound 92 | N-(3-((5-amino-1,3,4- oxa...)
Affinity DataIC50: 1.30nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376099BDBM376099(US9914736, Compound 95 | N-(1-(4-fluorophenyl)-3- ...)
Affinity DataIC50: 1.40nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376082BDBM376082(US9914736, Compound 78 | N-[1-(4-fluorophenyl)-3-(...)
Affinity DataIC50: 1.60nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376087BDBM376087(US9914736, Compound 83 | 5'-methyl-5-(3-(1-methyl-...)
Affinity DataIC50: 1.60nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376108BDBM376108(US9914736, Compound 104 | 2-fluoro-N-(1-(4- fluoro...)
Affinity DataIC50: 1.60nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376059BDBM376059(US9914736, Compound 55 | 2-chloro-5-(1-methyl-1H- ...)
Affinity DataIC50: 1.60nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376063BDBM376063(US9914736, Compound 59 | US9914736, Compound 80 | ...)
Affinity DataIC50: 1.70nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376029BDBM376029(US9914736, Compound 25 | N-(isothiazol-5-ylmethyl)...)
Affinity DataIC50: 1.70nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376098BDBM376098(US9914736, Compound 94 | N-(3-((5-aminopyrazin-2- ...)
Affinity DataIC50: 1.70nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376010BDBM376010(US9914736, Compound 6 | N-(5'-methyl-3-pyridin-2-y...)
Affinity DataIC50: 1.70nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376116BDBM376116(US9914736, Compound 112 | N-(3-((2,5-dioxoimidazol...)
Affinity DataIC50: 1.90nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376070BDBM376070(US9914736, Compound 66 | 3-(1-methyl-1H-pyrazol-3-...)
Affinity DataIC50: 2.30nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376115BDBM376115(US9914736, Compound 111 | N-(3-(2-amino-2-oxoethyl...)
Affinity DataIC50: 2.40nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376118BDBM376118(US9914736, Compound 114 | 2-fluoro-N-(1-(4- fluoro...)
Affinity DataIC50: 2.40nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376107BDBM376107(US9914736, Compound 103 | N-(3-(3- (aminomethyl)ph...)
Affinity DataIC50: 2.40nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376025BDBM376025(US9914736, Compound 21 | 4-chloro-3-(4-methyl-1,3-...)
Affinity DataIC50: 2.70nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376055BDBM376055(US9914736, Compound 51 | N-[3-(hydroxymethyl)-5'- ...)
Affinity DataIC50: 2.90nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376043BDBM376043(US9914736, Compound 39 | 2-chloro-N-(1-phenyl-3- p...)
Affinity DataIC50: 2.90nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376064BDBM376064(US9914736, Compound 60 | N-[1-(4-fluorophenyl)-3- ...)
Affinity DataIC50: 3nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376065BDBM376065(US9914736, Compound 61 | 3-(4-methyl-1,3-oxazol-2-...)
Affinity DataIC50: 3.10nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376044BDBM376044(US9914736, Compound 40 | 4-chloro-3-(1-methyl-1H- ...)
Affinity DataIC50: 3.20nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376062BDBM376062(US9914736, Compound 58 | 2-chloro-5-(1-methyl-1H- ...)
Affinity DataIC50: 3.40nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376105BDBM376105(US9914736, Compound 101 | 2-fluoro-N-(1-(4- fluoro...)
Affinity DataIC50: 3.40nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376094BDBM376094(US9914736, Compound 90 | N-(1-(4-fluorophenyl)-3-(...)
Affinity DataIC50: 3.60nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376100BDBM376100(US9914736, Compound 96 | N-(3-((1H-pyrazol-3- yl)m...)
Affinity DataIC50: 3.70nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376071BDBM376071(US9914736, Compound 67 | 3-(1-methyl-1H-pyrazol-3-...)
Affinity DataIC50: 3.70nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376102BDBM376102(US9914736, Compound 98 | N-(1-(4-fluorophenyl)-3-(...)
Affinity DataIC50: 3.80nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376069BDBM376069(US9914736, Compound 65 | 2-fluoro-N-(1-methyl-3- p...)
Affinity DataIC50: 4.5nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376112BDBM376112(US9914736, Compound 108 | 2-fluoro-5-(1-methyl-1H-...)
Affinity DataIC50: 4.60nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376093BDBM376093(US9914736, Compound 89 | 2-fluoro-N-(1-(4- fluorop...)
Affinity DataIC50: 4.80nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376088BDBM376088(US9914736, Compound 84 | 2-(5-(2-fluoro-5-(pyrimid...)
Affinity DataIC50: 4.90nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376007BDBM376007(US9914736, Compound 3 | N-(3-methyl-1-phenyl-1H- p...)
Affinity DataIC50: 5.40nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376015BDBM376015(US9914736, Compound 11 | 3-(1-methyl-1H-pyrazol-3-...)
Affinity DataIC50: 5.5nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376034BDBM376034(US9914736, Compound 30 | N-[1-(4-fluorophenyl)-3- ...)
Affinity DataIC50: 5.5nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376026BDBM376026(US9914736, Compound 22 | N-{5'-methyl-3-[2-oxo-2- ...)
Affinity DataIC50: 5.60nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376054BDBM376054(US9914736, Compound 50 | 1-methyl-5-({[3-(1-methyl...)
Affinity DataIC50: 5.70nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376053BDBM376053(US9914736, Compound 49 | 2-chloro-5-(1-methyl-1H- ...)
Affinity DataIC50: 5.80nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376036BDBM376036(US9914736, Compound 32 | N-(2-methyl-4-phenyl-1,3-...)
Affinity DataIC50: 6nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376095BDBM376095(US9914736, Compound 91 | N-(3-((2-aminopyrimidin-5...)
Affinity DataIC50: 6.10nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 376032BDBM376032(US9914736, Compound 28 | 3-(1-methyl-1H-pyrazol-3-...)
Affinity DataIC50: 6.60nMAssay Description: In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

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