Compile Data Set for Download or QSAR
Report error Found 264 Enz. Inhib. hit(s) with all data for entry = 10154
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517552BDBM517552(USRE48711, Example 159 | N-(6-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 3nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517579BDBM517579(USRE48711, Example 187 | N-(6-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 4nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517648BDBM517648(N-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Affinity DataIC50: 4nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517553BDBM517553(USRE48711, Example 160 | N-(6-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 4nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517555BDBM517555(USRE48711, Example 163 | N-(3-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 4nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517551BDBM517551(USRE48711, Example 158 | N-(3-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 5nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517600BDBM517600(USRE48711, Example 208 | N-(6-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 5nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517585BDBM517585(USRE48711, Example 193 | N-(6-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 5nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517506BDBM517506(USRE48711, Example 114 | N-(3-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 5nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517557BDBM517557(USRE48711, Example 165 | N-(3-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 5nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517558BDBM517558(USRE48711, Example 166 | N-(6-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 5nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517446BDBM517446(USRE48711, Example 54 | N-(6-(4-cyclopropyl-4H-1,2...)
Affinity DataIC50: 5nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517610BDBM517610(USRE48711, Example 218 | 3-(4-cyclopropyl-1H-imida...)
Affinity DataIC50: 5nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517580BDBM517580(USRE48711, Example 188 | N-(6-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 6nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517630BDBM517630(USRE48711, Example 238 | (S)-6-cyclopropyl-N-(3-(4...)
Affinity DataIC50: 6nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517471BDBM517471(USRE48711, Example 79 | N-(3-(4-cyclopropyl-4H-1,2...)
Affinity DataIC50: 6nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517521BDBM517521(USRE48711, Example 128 | N-(3-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 6nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517649BDBM517649(N-(3-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)phenyl)-...)
Affinity DataIC50: 6nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517492BDBM517492(USRE48711, Example 100 | 6-cyclopropyl-N-(6-(4-cyc...)
Affinity DataIC50: 6nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517638BDBM517638(USRE48711, Example 246 | 6-cyclopropyl-N-(6-(4-((2...)
Affinity DataIC50: 6nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517512BDBM517512(USRE48711, Example 120 | N-(3-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 6nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517643BDBM517643(USRE48711, Example 251 | N-(3-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 7nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517584BDBM517584(USRE48711, Example 192 | 3-(4-cyclopropyl-1H-imida...)
Affinity DataIC50: 7nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517490BDBM517490(USRE48711, Example 98 | N-(3-(4-cyclopropyl-4H-1,2...)
Affinity DataIC50: 7nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517620BDBM517620(USRE48711, Example 228 | 3-(4-cyclopropyl-1H-imida...)
Affinity DataIC50: 7nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517493BDBM517493(USRE48711, Example 101 | N-(6-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 7nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517559BDBM517559(USRE48711, Example 167 | N-(6-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 7nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517529BDBM517529(USRE48711, Example 136 | N-(3-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 7nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517562BDBM517562(USRE48711, Example 170 | 4-(4-cyclopropyl-1H-imida...)
Affinity DataIC50: 7nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517563BDBM517563(USRE48711, Example 171 | N-(3-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 7nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517601BDBM517601(3-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-cyclopr...)
Affinity DataIC50: 7nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517538BDBM517538(USRE48711, Example 145 | N-(3-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 7nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517570BDBM517570(USRE48711, Example 178 | N-(6-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 7nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517601BDBM517601(3-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-cyclopr...)
Affinity DataIC50: 7nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517640BDBM517640(USRE48711, Example 248 | 6-cyclopropyl-N-(6-(4-((2...)
Affinity DataIC50: 7nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517587BDBM517587(USRE48711, Example 195 | N-(6-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 8nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517619BDBM517619(USRE48711, Example 227 | 4-chloro-3-(4-cyclopropyl...)
Affinity DataIC50: 8nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517651BDBM517651(6'-cyclopropyl-N-(6-(4-cyclopropyl-4H-1,2,4-triazo...)
Affinity DataIC50: 8nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517429BDBM517429(USRE48711, Example 37 | 4-(1H-benzo[d]imidazol-1-y...)
Affinity DataIC50: 8nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517626BDBM517626(USRE48711, Example 234 | (S)-6-cyclopropyl-N-(6-(4...)
Affinity DataIC50: 8nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517498BDBM517498(USRE48711, Example 106 | N-(3-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 8nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517531BDBM517531(USRE48711, Example 138 | N-(3-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 8nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517435BDBM517435(USRE48711, Example 43 | N-(3-(4-cyclopropyl-4H-1,2...)
Affinity DataIC50: 8nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517502BDBM517502(USRE48711, Example 110 | N-(3-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 8nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517441BDBM517441(USRE48711, Example 49 | N-(3-(4-cyclopropyl-4H-1,2...)
Affinity DataIC50: 8nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517442BDBM517442(USRE48711, Example 50 | 6-cyclopropyl-N-(3-(4-cycl...)
Affinity DataIC50: 8nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517539BDBM517539(USRE48711, Example 146 | N-(3-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 8nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517443BDBM517443(USRE48711, Example 51 | N2'-(3-(4-cyclopropyl-4H-1...)
Affinity DataIC50: 8nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517575BDBM517575(USRE48711, Example 183 | 4-(4-cyclopropyl-2-methyl...)
Affinity DataIC50: 8nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 517544BDBM517544(USRE48711, Example 151 | N-(6-(4-cyclopropyl-4H-1,...)
Affinity DataIC50: 8nMAssay Description:The ability of compounds to inhibit ASK1 kinase activity was determined using a time resolved fluorescence resonance energy transfer [TR-FRET] assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

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