Reaction Details  Report a problem with these data
Cell Reactant:
v-Src SH2 Domain
Syringe Reactant:
BDBM22598
Meas. Tech.:
Isothermal Titration Calorimetry
Entry Date.:
2008-06-14
ΔG°:
-21.4000±n/a (kJ/mole)
pH:
6.0000±n/a
Log10Kb:
3
Temperature:
298.1500±n/a (K)
ΔHobs :
-5.5300±0.5300 (kJ/mole)
Corrected for ΔHioniz:
no
ΔS° :
0.0533±n/a (kJ/mole-K)
Comments:
ITC data were obtained through competition experiments using high affinity peptide (PQpYEEIPI) as the competitor.
Citation
 Taylor, JD; Gilbert, PJ; Williams, MA; Pitt, WR; Ladbury, JE Identification of novel fragment compounds targeted against the pY pocket of v-Src SH2 by computational and NMR screening and thermodynamic evaluation. Proteins 67:981-90 (2007) [PubMed]  Article
Cell React
Name:
Tyrosine-protein kinase transforming protein Src
Synonyms:
p60-Src | v-Src SH2 Domain | SRC_RSVSA | V-SRC
Type:
SH2 Domain
Mol. Mass.:
58884.32
Organism:
RSV-SR-A
Description:
P00524
Residue:
526
Sequence:
MGSSKSKPKDPSQRRRSLEPPDSTHHGGFPASQTPNKTAAPDTHRTPSRSFGTVATEPKLFGGFNTSDTVTSPQRAGALAGGVTTFVALYDYESWIETDLSFKKGERLQIVNNTEGNWWLAHSLTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVIEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMGNGEVLDRVERGYRMPCPPECPESLHDLMCQCWRRDPEERPTFEYLQAQLLPACVLEVAE
  
Syringe React
Name:
BDBM22598
Synonyms:
{[2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl]oxy}phosphonic acid | 4-trifluoromethylcoumarin phosphate | Fragment compound, 1
Type:
Small organic molecule
Emp. Form.:
C10H6F3O6P
Mol. Mass.:
309.99
SMILES:
OP(O)(=O)Oc1ccc2c(cc(=O)oc2c1)C(F)(F)F
Structure:
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