Reaction Details  Report a problem with these data
Cell Reactant:
Mitogen-Activated Protein Kinase 9 (JNK2) Mutant (R127A)
Syringe Reactant:
BDBM26057
Meas. Tech.:
Isothermal Titration Calorimetry
Entry Date.:
12/18/08
pH:
7.4±n/a
Log10Kb:
4.5
Temperature:
298.15±n/a (K)
Corrected for ΔHioniz:
no
Citation
 Stebbins, JL; De, SK; Machleidt, T; Becattini, B; Vazquez, J; Kuntzen, C; Chen, LH; Cellitti, JF; Riel-Mehan, M; Emdadi, A; Solinas, G; Karin, M; Pellecchia, M Identification of a new JNK inhibitor targeting the JNK-JIP interaction site. Proc Natl Acad Sci U S A 105:16809-13 (2008) [PubMed]  Article
Cell React
Name:
Mitogen-Activated Protein Kinase 9 (JNK2) Mutant (R127A)
Synonyms:
n/a
Type:
Serine/threonine-protein kinase
Mol. Mass.:
48045.37
Organism:
Human
Description:
n/a
Residue:
424
Sequence:
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHEAMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR
  
Syringe React
Name:
BDBM26057
Synonyms:
4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-4H-1,2,4-triazol-3-ol | BI-78D3
Type:
Small organic molecule
Emp. Form.:
C13H9N5O5S2
Mol. Mass.:
379.371
SMILES:
[O-][N+](=O)c1cnc(Sc2n[nH]c(=O)n2-c2ccc3OCCOc3c2)s1
Structure:
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