Reaction Details  Report a problem with these data
Cell Reactant:
DNA Gyrase
Syringe Reactant:
BDBM285
Meas. Tech.:
Isothermal Titration Calorimetry
Entry Date.:
2003-03-31
ΔG°:
-35.1000±0.2000 (kJ/mole)
pH:
7.5000±n/a
Log10Kb:
5
Temperature:
298.1500±n/a (K)
ΔH° :
-18.0000±0.5000 (kJ/mole)
ΔHobs :
-18.0000±0.5000 (kJ/mole)
Corrected for ΔHioniz:
not known
ΔCp :
-0.6200±0.0600 (kJ/mole)
ΔS° :
0.0574±0.0010 (kJ/mole-K)
Citation
 Lafitte, D; Lamour, V; Tsvetkov, PO; Makarov, AA; Klich, M; Deprez, P; Moras, D; Briand, C; Gilli, R DNA gyrase interaction with coumarin-based inhibitors: the role of the hydroxybenzoate isopentenyl moiety and the 5'-methyl group of the noviose. Biochemistry 41:7217-23 (2002) [PubMed]  Article
Cell React
Source:
Bacterial clone
Purity:
97%
Prep. Method:
Gilbert, E. J., and Maxwell, A. (1994) Mol. Microbiol. 12, 365-373.
Name:
DNA gyrase subunit B
Synonyms:
gyrB
Type:
Enzyme
Mol. Mass.:
89941.28
Organism:
Escherichia coli
Description:
C3SLN3
Residue:
804
Sequence:
MSNSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEIIVTIHADNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSQKLELVIQREGKIHRQIYEHGVPQAPLAVTGETEKTGTMVRFWPSLETFTNVTEFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGGIKAFVEYLNKNKTPIHPNIFYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDKEGYSKKAKVSATGDDAREGLIAVVSVKVPDPKFSSQTKDKLVSSEVKSAVEQQMNELLAEYLLENPTDAKIVVGKIIDAARAREAARRAREMTRRKGALDLAGLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGRDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIVERGHVYIAQPPLYKVKKGKQEQYIKDDEAMDQYQISIALDGATLHTNASAPALAGEALEKLVSEYNATQKMINRMERRYPKAMLKELIYQPTLTEADLSDEQTVTRWVNALVSELNDKEQHGSQWKFDVHTNAEQNLFEPIVRVRTHGVDTDYPLDHEFITGGEYRRICTLGEKLRGLLEEDAFIERGERRQPVASFEQALDWLVKESRRGLSIQRYKGLGEMNPEQLWETTMDPESRRMLRVTVKDAIAADQLFTTLMGDAVEPRRAFIEENALKAANIDI
  
Syringe React
Source:
Synthesis
Prep. Method:
Ferroud, D., Collard, J., Klich, M., Dupuis-Hamelin, C., Mauvais, P., Lassaigne, P., Bonnefoy, A., and Musicki, B.(1999) Bioorg. Med. Chem. Lett. 9, 2881-2886.
Name:
BDBM285
Synonyms:
{[7-({3-hydroxy-5-methoxy-6-methyl-4-[(5-methyl-1H-pyrrol-2-yl)carbonyloxy]oxan-2-yl}oxy)-8-methyl-2-oxo-2H-chromen-4-yl]methyl}phosphonate | Coumarin-Based, DNA Gyrase Inhibitor | RU 64136
Type:
Antibiotic
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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