Reaction Details  Report a problem with these data
Cell Reactant:
Leucyl-tRNA synthetase K510E mutant (K510E)
Syringe Reactant:
BDBM163674
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
2016-02-16
ΔG°:
-27.0000±0.4000 (kJ/mole)
pH:
8.0000±0.0000
Temperature:
298.1500±0.0000 (K)
ΔH° :
-6.3000±3.0000 (kJ/mole)
ΔS° :
-0.0670±0.0100 (kJ/mole-K)
Citation
 Zhao, H; Palencia, A; Seiradake, E; Ghaemi, Z; Cusack, S; Luthey-Schulten, Z; Martinis, S Analysis of the Resistance Mechanism of a Benzoxaborole Inhibitor Reveals Insight into the Leucyl-tRNA Synthetase Editing Mechanism. ACS Chem Biol 10:2277-85 (2015) [PubMed]  Article 
Cell React
Name:
Leucine--tRNA ligase [A132I,E138V,K510E,I952T]
Synonyms:
Leucyl-tRNA synthetase K510E mutant (K510E)
Type:
Protein
Mol. Mass.:
125396.76
Organism:
Yeast
Description:
A0A1D8PS12[A132I,E138V,K510E,I952T]
Residue:
1097
Sequence:
MSGPVTFEKTFRRDALIDIEKKYQKVWAEEKVFEVDAPTFEECPIEDVEQVQEAHPKFFATMAYPYMNGVLHAGHAFTLSKVEFATGFQRMNGKRALFPLGFHCTGMPIKAAADKIKREVELFGSDFSKAPIDDEDAVESQQPAKTETKREDVTKFSSKKSKAAAKQGRAKFQYEIMMQLGIPREEVAKFANTDYWLEFFPPLCQKDVTAFGARVDWRRSMITTDANPYYDAFVRWQINRLRDVGKIKFGERYTIYSEKDGQACLDHDRQSGEGVGPQEYVGIKIRLTDVAPQAQELFKKENLDVKENKVYLVAATLRPETMYGQTCCFVSPKIDYGVFDAGNGDYFITTERAFKNMSFQNLTPKRGYYKPLFIINGKTLIGSRIDAPYAVNKNLRVLPMETVLATKGTGVVTCVPSDSPDDFVTTRDLANKPEYYGIEKDWVQTDIVPIVHTEKYGDKCAEFLVNDLKIQSPKDSVQLANAKELAYKEGFYNGTMLIGKYKGDKVEDAEPKVKQDLIDEGLAFVYNEPESQVISRSGDDCCVSLEDQWYIDYGEEAWLGEALECLKNMETYSKETRHGFEGVLAWMKNWAVTRKFGLGTKLPWDPQYLVESLSDSTVYMAYYTIDRFLHSDYYGKKAGKFDIKPEQMTDEVFDYIFTRRDDVETDIPKEQLKEMRREFEYFYPLDVRVSGKDLIPNHLTFFIYTHVALFPKRFWPRGVRANGHLLLNNAKMSKSTGNFMTLEQIIEKFGADASRIAMADAGDTVEDANFDEANANAAILRLTTLKDWCEEEVKNQDKLRTGDYDSFFDAAFENEMNDLIEKTYQQYTLSNYKQALKSGLFDFQIARDIYRESVNTTGIGMHKDLVLKYIEYQALMLAPIAPHFAEYLYREVLGKNGSVQTSKFPRASKPVSKAILDASEYVRSLTRSIREAEGQALKKKKGKSDVDGSKPTSLTVLVSNTFPEWQDNYIELVRELFEQNKLDDNNVIRQKVGKDMKRGMPYIHQIKTRLATEDADTVFNRKLTFDEIDTLKNVVEIVKNAPYSLKVEKLEILSFNNGETKGKNIISGEDNIELNFKGKIMENAVPGEPGIFIKNVE
  
Syringe React
Name:
BDBM163674
Synonyms:
AN2690-AMP
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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