Reaction Details 
Report a problem with these data
Report a problem with these dataCell Reactant:
Transthyretin
Syringe Reactant:
BDBM138365
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
2022-08-28
ΔG°:
-9.04±0.19 (kcal/mole)
pH:
7.5000±0.0000
Temperature:
298.1500±0.0000 (K)
ΔH° :
-6.67±0.22 (kJ/mole)
ΔS° :
0.01±0 (kJ/mole-K)
Citation
Graef, IA; Alhamadsheh, MM Identification of stabilizers of multimeric proteins US Patent US11337935 Publication Date 5/24/2022 Cell React
Name:
Transthyretin
Synonyms:
Transthyretin (TTR) | ATTR | Prealbumin | TBPA | TTHY_HUMAN | TTR | PALB
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Human
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
Syringe React
Name:
BDBM138365
Synonyms:
US8877795, 14 | US10278929, Compound 14 | US11337935, Compound 14
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CN1C(=N)NC(=O)\C1=C\c1cc(Br)c(O)c(Br)c1
Structure:
