Cell Reactant:
BDBM14836
Syringe Reactant:
5-hydroxytryptamine receptor 2A
Meas. Tech.:
Isothermal Titration Calorimetry
Entry Date.:
04/16/07
pH:
7±n/a
Temperature:
298.15±n/a (K)
ΔHobs :
-11.6±0.7 (kJ/mole)
Corrected for ΔHioniz:
no
Citation
 Kroe, RRRegan, JProto, APeet, GWRoy, TLandro, LDFuschetto, NGPargellis, CAIngraham, RH Thermal denaturation: a method to rank slow binding, high-affinity P38alpha MAP kinase inhibitors. J Med Chem 46:4669-75 (2003) [PubMed]  Article
Cell React
Name:
BDBM14836
Synonyms:
3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-phenylurea | CHEMBL315100 | Dopamine D2 receptor and serotonin 2a receptor | diaryl urea compound 5
Type:
Small organic molecule
Emp. Form.:
C21H24N4O
Mol. Mass.:
348.4415
SMILES:
Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccccc1)C(C)(C)C
Structure:
Search PDB for entries with ligand similarity:
Syringe React
Source:
The full-length open reading frame of murine p38 alpha was cloned and expressed in E. coli.
Prep. Method:
Soluble murine p38R was extracted from cell pellets and purified by using ion-exchange chromatography. Column fractions were concentrated, analyzed by SDS-PAGE, and pooled based on purity.
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV