Reaction Details  Report a problem with these data
Cell Reactant:
Histone deacetylase 8 (HDAC8)
Syringe Reactant:
BDBM152692
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
2015-09-14
ΔG°:
-31.0000±2.0000 (kJ/mole)
pH:
7.5000±0.0000
Temperature:
25.0000±0.0000 (K)
ΔH° :
-18.9000±n/a (kJ/mole)
ΔHobs :
-19.0000±1.0000 (kJ/mole)
ΔS° :
0.0420±0.0030 (kJ/mole-K)
Citation
 Singh, RK; Suzuki, T; Mandal, T; Balsubramanian, N; Haldar, M; Mueller, DJ; Strode, JA; Cook, G; Mallik, S; Srivastava, DK Thermodynamics of binding of structurally similar ligands to histone deacetylase 8 sheds light on challenges in the rational design of potent and isozyme-selective inhibitors of the enzyme. Biochemistry 53:7445-58 (2014) [PubMed]  Article
Cell React
Name:
Histone deacetylase 8
Synonyms:
HD8 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 | HDAC8_HUMAN | HDAC8 | HDACL1
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Human
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Syringe React
Name:
BDBM152692
Synonyms:
Thiol-SAHA (t-SAHA)
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: