Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM507132
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding
EC50
2.60±n/a nM
Citation
Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Horne, DB; Houze, J; Kaller, MR; Kayser, F; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yang, K; Yeh, W Heteroaryl-substituted triazoles as APJ receptor agonists US Patent US11046680 Publication Date 6/29/2021
More Info.:
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
Inhibitor
Name:
BDBM507132
Synonyms:
US11046680, Example 3.0
Type:
Small organic molecule
Emp. Form.:
C21H25N9O4S2
Mol. Mass.:
531.611
SMILES:
COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1-c1nc(C)cs1 |r,wU:16.17,18.19,(1.25,1.37,;-.08,.6,;-1.42,1.37,;-1.42,2.91,;-2.75,3.68,;-4.09,2.91,;-4.09,1.37,;-5.42,.6,;-6.75,1.37,;-2.75,.6,;-2.75,-.94,;-1.51,-1.85,;-.04,-1.37,;1.29,-2.14,;2.63,-2.91,;-.04,-2.91,;2.63,-1.37,;2.63,.17,;3.96,-2.14,;3.96,-3.68,;5.29,-1.37,;6.63,-2.14,;7.96,-1.37,;7.96,.17,;9.3,.94,;6.63,.94,;5.29,.17,;-1.98,-3.31,;-3.52,-3.31,;-4,-1.85,;-5.46,-1.37,;-6.55,-.28,;-7.92,-.98,;-9.3,-.28,;-7.68,-2.5,;-6.16,-2.74,)|