Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 3
Ligand
BDBM511441
Substrate
n/a
Meas. Tech.
Receptor [35S] GTPgammaS Binding Assays
EC50
>60000±n/a nM
Citation
 Dyckman, AJ; Li, L; Dhar, TG; Xiao, H Oxime ether compounds US Patent  US11059784 Publication Date 7/13/2021 
Target
Name:
Sphingosine 1-phosphate receptor 3
Synonyms:
C9orf108 | C9orf47 | EDG3 | Endothelial differentiation G-protein coupled receptor 3 | S1P receptor 3 | S1P receptor Edg-3 | S1P3 | S1PR3 | S1PR3_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor 3 (S1P3) | Sphingosine 1-phosphate receptor Edg-3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42278.13
Organism:
Human
Description:
Q99500
Residue:
378
Sequence:
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAPSSCIMDKNAALQNGIFCN
  
Inhibitor
Name:
BDBM511441
Synonyms:
US11059784, Example 45
Type:
Small organic molecule
Emp. Form.:
C22H26F3N2O5P
Mol. Mass.:
486.4212
SMILES:
CC(=NOCc1ccc(cc1)C(F)(F)F)c1ccc(cc1)[C@@H]1CC[C@](N)(COP(O)(O)=O)C1 |r,w:2.2|
Structure:
Search PDB for entries with ligand similarity: