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Target
Serine hydroxymethyltransferase, cytosolic
Ligand
BDBM512936
Substrate
n/a
Meas. Tech.
SHMT1 and SHMT2 Activity Assays
IC50
<1000±n/a nM
Citation
 Mainolfi, N SHMT inhibitors and uses thereof US Patent  US11091451 Publication Date 8/17/2021 
Target
Name:
Serine hydroxymethyltransferase, cytosolic
Synonyms:
GLYC_HUMAN | Glycine hydroxymethyltransferase | SHMT | SHMT1 | Serine methylase
Type:
PROTEIN
Mol. Mass.:
53091.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_745716
Residue:
483
Sequence:
MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQKVAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGLPDF
  
Inhibitor
Name:
BDBM512936
Synonyms:
US11091451, Compound I-8
Type:
Small organic molecule
Emp. Form.:
C22H22N2O5S
Mol. Mass.:
426.485
SMILES:
COc1cc(-c2nc(CC(=O)NC(C)(C)C(O)=O)cs2)c(cc1O)-c1ccccc1
Structure:
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