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Target
Serine hydroxymethyltransferase, cytosolic
Ligand
BDBM512960
Substrate
n/a
Meas. Tech.
SHMT1 and SHMT2 Activity Assays
IC50
5500±n/a nM
Citation
 Mainolfi, N SHMT inhibitors and uses thereof US Patent  US11091451 Publication Date 8/17/2021 
Target
Name:
Serine hydroxymethyltransferase, cytosolic
Synonyms:
GLYC_HUMAN | Glycine hydroxymethyltransferase | SHMT | SHMT1 | Serine methylase
Type:
PROTEIN
Mol. Mass.:
53091.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_745716
Residue:
483
Sequence:
MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQKVAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGLPDF
  
Inhibitor
Name:
BDBM512960
Synonyms:
US11091451, Compound I-25
Type:
Small organic molecule
Emp. Form.:
C18H21ClN2O3S
Mol. Mass.:
380.889
SMILES:
CC(C)c1cc(Cl)ccc1-c1nc(CC(=O)NC(C)(C)C(O)=O)cs1
Structure:
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