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Target
Receptor-interacting serine/threonine-protein kinase 1 [8-327]
Ligand
BDBM530216
Substrate
n/a
Meas. Tech.
Fluorescent Polarization Binding (FP Binding) Assay
IC50
>1000±n/a nM
Citation
 De Vicente Fidalgo, J; Estrada, AA; Feng, JA; Fox, B; Francini, CM; Hale, CR; Hu, C; Leslie, CP; Osipov, M; Serra, E; Sweeney, ZK; Thottumkara, A Kinase inhibitors and uses thereof US Patent  US11203600 Publication Date 12/21/2021 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 1 [8-327]
Synonyms:
RIP | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) (8-327)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36497.31
Organism:
Homo sapiens (Human)
Description:
aa 8-327
Residue:
320
Sequence:
NVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVA
  
Inhibitor
Name:
BDBM530216
Synonyms:
Preparation of 4-[(4R)-3,3-difluoro-4-methyl-1-pyrimidin-2-yl-piperidine-4-carbonyl]-3,5-dihydro-2H-pyrido[3,4-f][1,4]oxazepine-9-carbonitrile and 4-[(4S)-3,3-difluoro-4-methyl-1-pyrimidin-2-yl-piperidine-4-carbonyl]-3,5-dihydro-2H-pyrido [3,4-f][1,4]oxazepine-9-carbonitrile | US11203600, Example 297 | US11203600, Example 298
Type:
Small organic molecule
Emp. Form.:
C19H17F3N6O2
Mol. Mass.:
418.3725
SMILES:
FC1(F)CN(CC[C@@]1(F)C(=O)N1CCOc2c(C1)cncc2C#N)c1ncccn1 |r|
Structure:
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