Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM530572
Substrate
n/a
Meas. Tech.
DGAT2 enzymatic activity assay
IC50
28±n/a nM
Citation
 Yeon-Hee, L; R., AE; Jianming, B; Chen, C; P., RJ; Helen, SE PREPARATION OF BENZIMIDAZOLONE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS WIPO WO2022076495 Publication Date -1/14/2022 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Human
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM530572
Synonyms:
WO2022076495, EXAMPLE 18
Type:
Small organic molecule
Emp. Form.:
C23H27FN4O5S
Mol. Mass.:
490.548
SMILES:
CCOc1cc(c(F)cn1)-n1c2ccc(cc2n(C(C)C)c1=O)C(=O)N[C@]1(C)CCS(=O)(=O)C1 |wU:26.29,wD:26.28,(3.79,7.77,;2.76,6.63,;3.23,5.16,;2.2,4.02,;2.68,2.55,;1.65,1.41,;.14,1.73,;-.89,.58,;-.33,3.19,;.7,4.34,;2.13,-.06,;3.59,-.53,;4.92,.24,;6.26,-.53,;6.26,-2.07,;4.92,-2.84,;3.59,-2.07,;2.13,-2.55,;1.65,-4.01,;.14,-4.33,;2.68,-5.16,;1.22,-1.3,;-.32,-1.3,;7.59,-2.84,;7.59,-4.38,;8.93,-2.07,;10.26,-2.84,;9.35,-4.09,;10.89,-1.44,;12.42,-1.6,;12.74,-3.1,;14.2,-2.63,;13.36,-4.51,;11.4,-3.87,)|
Structure:
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