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Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM530627
Substrate
n/a
Meas. Tech.
DGAT2 enzymatic activity assay
IC50
1.80±n/a nM
Citation
 Yeon-Hee, L; R., AE; Jianming, B; Chen, C; P., RJ; Helen, SE PREPARATION OF BENZIMIDAZOLONE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS WIPO WO2022076495 Publication Date -1/14/2022 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Human
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM530627
Synonyms:
WO2022076495, EXAMPLE 68b
Type:
Small organic molecule
Emp. Form.:
C27H33F2N3O6S
Mol. Mass.:
565.629
SMILES:
C[C@@H](n1c2cc(ccc2n(-c2cccc(OCC(F)F)c2)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1)C(C)(C)O |r|
Structure:
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