Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM530629
Substrate
n/a
Meas. Tech.
DGAT2 enzymatic activity assay
IC50
3.90±n/a nM
Citation
 Yeon-Hee, L; R., AE; Jianming, B; Chen, C; P., RJ; Helen, SE PREPARATION OF BENZIMIDAZOLONE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS WIPO WO2022076495 Publication Date -1/14/2022 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Human
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM530629
Synonyms:
WO2022076495, EXAMPLE 69b
Type:
Small organic molecule
Emp. Form.:
C26H33FN4O6S
Mol. Mass.:
548.627
SMILES:
CCOc1cc(c(F)cn1)-n1c2ccc(cc2n([C@H](C)C(C)(C)O)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1 |r,wD:18.20,(-4.38,-5.29,;-2.87,-4.97,;-1.84,-6.12,;-.33,-5.8,;.14,-4.33,;1.65,-4.01,;2.68,-5.16,;4.19,-4.84,;2.2,-6.62,;.7,-6.94,;2.13,-2.55,;3.59,-2.07,;4.92,-2.84,;6.26,-2.07,;6.26,-.53,;4.92,.24,;3.59,-.53,;2.13,-.06,;1.65,1.41,;.14,1.73,;2.68,2.55,;4.19,2.23,;3.16,1.09,;2.2,4.02,;1.22,-1.3,;-.32,-1.3,;7.59,.24,;7.59,1.78,;8.93,-.53,;10.26,.24,;10.79,-1.21,;9.27,1.42,;9.8,2.86,;11.31,3.13,;10.79,4.58,;12.65,3.9,;12.3,1.95,;11.78,.5,)|
Structure:
Search PDB for entries with ligand similarity: