Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM530648
Substrate
n/a
Meas. Tech.
DGAT2 enzymatic activity assay
IC50
2.10±n/a nM
Citation
 Yeon-Hee, L; R., AE; Jianming, B; Chen, C; P., RJ; Helen, SE PREPARATION OF BENZIMIDAZOLONE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM530648
Synonyms:
1-(5-(Difluoromethoxy)-2-fluorophenyl)-3-isopropyl-N-(4-methyl-l,1-dioxidotetrahydro-2H-thiopyran-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxamide | WO2022076495, EXAMPLE 79
Type:
Small organic molecule
Emp. Form.:
C24H26F3N3O5S
Mol. Mass.:
525.541
SMILES:
CC(C)n1c2cc(ccc2n(-c2cc(OC(F)F)ccc2F)c1=O)C(=O)NC1(C)CCS(=O)(=O)CC1 |(.37,-5.69,;1.4,-4.54,;2.91,-4.86,;.92,-3.08,;-.54,-2.6,;-1.88,-3.37,;-3.21,-2.6,;-3.21,-1.06,;-1.88,-.29,;-.54,-1.06,;.92,-.59,;1.4,.88,;.37,2.02,;.85,3.49,;-.19,4.63,;-1.69,4.31,;-2.72,5.46,;-2.17,2.85,;2.35,3.81,;3.38,2.66,;2.91,1.2,;3.94,.05,;1.83,-1.83,;3.37,-1.83,;-4.54,-3.37,;-4.54,-4.91,;-5.88,-2.6,;-7.21,-3.37,;-7.21,-1.83,;-8.54,-2.6,;-9.88,-3.37,;-9.88,-4.91,;-11.21,-5.68,;-9.88,-6.45,;-8.54,-5.68,;-7.21,-4.91,)|
Structure:
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