Reaction Details Report a problem with these data
Target
Phosphatidylinositol 4-kinase
Ligand
BDBM533856
Substrate
n/a
Meas. Tech.
PI(4)K enzymatic Assay
IC50
>1000±n/a nM
Citation
 Michael, YJ; Robert, TM; Peichao, L COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CRYPTOSPORIDIOSIS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Phosphatidylinositol 4-kinase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
128976.50
Organism:
n/a
Description:
Q5CVD3
Residue:
1114
Sequence:
MVEGWLTTSKSMSGLFGKSLISKQKSTSGSINFNDDELTDNIVVDLGDFSNNNNNKSDNLYSRKDSKGGEFDKSKGSLLRLFQSDVFDAHLHLYYIYHHKEFGVHEYLVNLLYERSDEILWYLPQLCEISLNRFEKSSLWKYFLDKSSENMNFSLILSWMYQAMNEDNIPLISEYAQNMLQEIEMAMVNSKLKPDIRYIEKRLYFWRRSNLSVFQSLCNQNMKLNDIEDEFKDNDNTMLMNRENTNTQLSLAIYSTLPSSETINLNESDDLNQDDNNRIISSDINTNTIPNNNSKTIKLSSCDVLPDIWIYRIINDDFSCENKAKIEYIQTKLGLINRQFKNLYSNATCAAYYNPNPGTSLNYKSGVSSSAFGSLNSGFLPTSIISGSSSFGTFSSGGNSNKVSIPYFFFSKLGSPFDLIDVNKIINDIQFRSKSRINLINKSHNFNVQDNSSEDTVSIPKTPRDVIRITHPFSPCSETESETNNLDLDDNGTFEEIKLAPDSNVCSDNDNKKIPILTPNSTKIIECLENLSNENSGSPIQLNDDILRNEEIFKVYISEIEKESETLYYLLKQHRYNYFNRVNQLVSQFLEISNYLQSNINKEHRCEILEFIIEELNLWLFYSRFSISISRTTFLLNSISLPMPSFNNEFCSRFSENDSFNSNNKDGNSKGIIGFSHSDYIMDKGLCSLNNCQFLRIIPNECKIYNSRKRVHFLLAIEIADLDDQDYELGKNSQDLISKDILNYLKNHGIKLKTDNNDENQNRSQDILLNFLNILSVGISESIDMGLSQEDFNQITFIDNKDSDEIEDSSIHDNELSDEDIFINKDWPQETWSSKIKRYRKESPYSKLKSWGIKTLLLKSSDDLRQEYLASQLLQQFDWIFKINKLPLWLHPYEILVIGSHGGFIEYIQDTFSIDSLKRRFQTDNLLNCFDQLFKDEELKSKARKCFVESHAAYSLVSYFLQVKDRHNGNFLIDKHGHIIQIDYGFMLSNSPGNVNFEQSPFKLTQEFLDVMMGENSSDFQYFQQLIIKGFLASRKHVDQIVLTIESMTSASKLPCFSLFTNKEYFIQDIRDRFFLHLTEEQCVVKVTELIQSSINNWRSIQYDAFQRITNGIL
 
Inhibitor
Name:
BDBM533856
Synonyms:
Methyl 5-(3-(4-carbamoylphenyl)pyrazolo[1,5-a]pyridine-5-carboxamido)-2-chlorobenzoate (1.23) | WO2022079616, Example 1.23
Type:
Small organic molecule
Emp. Form.:
C23H17ClN4O4
Mol. Mass.:
448.858
SMILES:
COC(=O)c1cc(NC(=O)c2ccn3ncc(-c4ccc(cc4)C(N)=O)c3c2)ccc1Cl
Structure:
Search PDB for entries with ligand similarity: