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Target
PI3K/PI4K catalytic domain-containing protein
Ligand
BDBM533860
Substrate
n/a
IC50
>1000±n/a nM
Citation
 Michael, YJ; Robert, TM; Peichao, L COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CRYPTOSPORIDIOSIS WIPO 0:0 (2022) [PubMed] 
Target
Name:
PI3K/PI4K catalytic domain-containing protein
Synonyms:
PI3K/PI4K domain-containing protein
Type:
Protein
Mol. Mass.:
252626.40
Organism:
n/a
Description:
A0A0S4TH36
Residue:
2159
Sequence:
MSCGNKYFWNLEGHDPALALLDLFENGKKYNSLETLVDFLSKNIVLLENMKNNSNSKKEGLFNFLFLFQKLNGRPAENENPEPVPLLSLDLKLADTILVQKALLRDLVFLLGNREFDVFRRLYSLLIKFAPLDLKDLISIEKNHGSMICIYFTIYFSILLNIFGYENIGEFRKGEEIEELKLNWINKFVSQINDLLDYFIDKKTNLLRITDINNDCLILIFALILYLIISIIDIGNDKITEFKLAIIKLIKIQLSNLMFNYWYLKILLIIIERIGMDLTVSELVLVVLQYQKFIGEQSIKIENNNSFDKSMNKLGVFETHIVTHLCRTWVVKEITLKKQLMEFVEQFIFTYGKLKEKKFDDYFLKKEDDLSMLDPINIVFIKLVSLFSKAFGVSMTGIDKEEYKNKEISDSKEIDSLVLLNLLEELLQGRRSQKICGLILFDSIRMLVTVLTILVDHRNFESENYDIKREIIQNDLVIVNLHKGGWNLKAYKCIDLIEKLFEIITHLIIRYKEDHKELNNSVNTISSVSSSSTGSIFKTTSFDISLFLIVWKNYVTLITRKEYRTDPIIFNKSIHLISLYLVSRKYKLDMLCEITFPISEYSDNLPILLDERYSDLIDLWTILWRNYLNENTNLFYNKRDEVENIFTVPNINYFFEYLRILDQVITQNNGISSPGLALSDKESMYTQKFTTKVLELTGIISSILICHKIVHSSDRHNTLMAILSASENPRIMSEYIYKQATNSLQFDGAYIYNCLKFFREKWSSSIKIRVFSLISDLYISIMKQSLFQFIQCLLSNFSVRGGIFEKSFALFKVRGMRGIISEEDFEVLQQKLTNIFSYSNSDLDGDLTSSLIKNEIFFGCYSIDLYYTINNIQKGWQSPSLSITPSSPKTFLNKKRHSSLMITDSEDVYSIINRLNPLFDQLINDDDYLKLFMDTVGEISKCYFYFLFENKSSDSGERSLIDQISNFSTIFGVKFEDEKFMASMNLKNELLKNVNYSNPTEEVIVERFNYKFYSQLIIRMIYLCTWMIVDNNYESYKSLSDLFAEKILNGLFGISNDEGGNHTSSYKFSQGNDQFDRFKSSLTDDYVLEHYTKFVCIIWSIISSMDPESIYKSYIKILERESLSYYQLYILLVFLIESSDWFIHHGYFQHINLLKILRQVELMTCLSSAYLQVKDENKEKTSQINSSDLHLKILLVCLIQKSITVEISKEVPLECYKKKHPTILKTNHNDLDIPQIRIYKFNNKSNQRDAYINGGRSMISTSYFLSCRILPYLWSFYESYPTYKDIYTRLLQSSTQLTTYLDNLCVNLYETKNWQKMMNNFNNVHLESSVEIYDNRLIPYNQYIVLEYIWEYFINGNTMILIEKYISALIFSIYSSKKVGFFEVWLLLSLWKRYPARIYRHMMKTSSTWIVPFLMDHLIHYSILVKNNYIGISSPKNDLIRVFNNIELENTFSFLLYHYHPQYYHDRMSGKYFWYNASSEQGYLNKINSHNTEIKGLVMNCRYTQGNHQLVLQFHDYLHYIGHSLPFPVVIYLLSNQFSSEKKKFMSNSHHFHNYFHHSLYTSTLIVWSCVRSLLLSQESEWELLLLQYMEIIKSNKRNNQLVLTGLLDMALKSTRFSQILCIYTNNPNSPIMNIFQKSLFKECDFLLTCKSMKSSEENIERNEDQNMNGKYEKRNSSEIHGKGVINRLRTVQDSMEGLNLRMSSVSSLINKCFDTISETSENLNRSSLNILQFENKKHSLANVQFSFFYILCQLGEMAKYRNRKEGGLGLPIEEDDNPSALIGRLNSKEIAQLKSEIAQDLLAKIENVIQRKEYKNVPFLNTNMLKSSENKTKLLSIKKINKLKILQSAKNIPYLLSLQLTDHNSDNQDTLVDISKIEPEQDYEMTINLIVKCNDDCRQDVITMQYIHVFQKIFELYNIPVWLYPYRILPMMFKDINNSVIYGGIIEFIEDSISLHEIHELHSEGGLKAYYESTFGGKNSHIKKLENDNNVSYEQARYNFISSLAGYSIACYVLQIKDRHNGNILITKNGHIIHIDYGFIFDISPGNNLHFERAAFKVTQEMLDFMDDQVDLFDDLCLSGFLAVREHADLLLSLTQMLINSGIPCFRGETIKKLKERLLLNFSQQQASNIFSKKIHSAHNHITTKGYDLVQFIQQGIK
 
Inhibitor
Name:
BDBM533860
Synonyms:
Methyl 5-(3-(4-carbamoylphenyl)-N-methylpyrazolo[1,5-a]pyridine-5-carboxamido)-2-(trifluoromethoxy)benzoate (1.25) | WO2022079616, Example 1.25
Type:
Small organic molecule
Emp. Form.:
C25H19F3N4O5
Mol. Mass.:
512.4374
SMILES:
COC(=O)c1cc(ccc1OC(F)(F)F)N(C)C(=O)c1ccn2ncc(-c3ccc(cc3)C(N)=O)c2c1
Structure:
Search PDB for entries with ligand similarity: