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Target
Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands
Ligand
BDBM50389688
Substrate
n/a
Meas. Tech.
Luminescent Kinase Assay
IC50
3.20±n/a nM
Citation
 Van Voorhis, WC; Hol, WG; Larson, ET; Maly, DJ; Merritt, E; Ojo, KK Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases US Patent  US11247972 Publication Date 2/15/2022 
Target
Name:
Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands
Synonyms:
cGMP-dependent protein kinase (CpCDPK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
80612.61
Organism:
Cryptosporidium parvum (strain Iowa II)
Description:
Q5CTY5
Residue:
718
Sequence:
MMGQGQNALNGVCSRRYEKDSIEINKNKEVRRKQSNKRGNFPAHNMTHGKPEYLKEAVDRLINHGNIVGNSPDRYLAKERKSQASCSTSDPTSPLAYRNGNDNYFEQYEICDLIELTSEMALSNESRFESLSEYESIPKLSPSTTVMGITDVSATNTSNSNSATPTESEKGSGPKLSLTEGKFRREGLIPACKGSIHSDYIIDSGRIGKGTYGSVKSGTNRLTGCIRAIKTIPLTRVEALDNFMKEINILKNLDHPNIVKLYETYQDKENIYLVMELCSGGELFDRIISQGSFDEIYAANLMKQVLSTICYCHDHGIVHRDLKPENFLFLNKNYNAPLKIIDFGLAARVNNEDTSLNTRAGTPYYVAPEVLQGKYDKQCDMWSLGVILYILLCGYPPFHGSNDSIILHKVQKGVYAFKEEDWKHVSFLAIDLIRKLLTYNPSERITARDALNHPWITRFADDILFLSPRNYFYSNDGFMKTGIVSSDYIDSSINNLKALECQQKPRNCNLMGSRRNGYIKGGLRYCRSKRRSISSSSGLNLLSNFRAFHKYNRFMKVALTVIAQQMTESQISNLKEAFILLDANCDGTLTPQEIITGLKNSGITELPSDLLAILNDIDSDGSGSIDYTEFIAATLDSKQYSKEQVCWAAFKVFDQDGNGKITANELLNVFSYNSEQGSAGINDKALSDVKNMIKEVDVDGDGEIDFQEFLEMFRRSNS
  
Inhibitor
Name:
BDBM50389688
Synonyms:
CHEMBL2069315 | US10544104, Compound 36 | US11247972, Compound 36 | US9765037, Compound 36
Type:
Small organic molecule
Emp. Form.:
C24H26N6O
Mol. Mass.:
414.5028
SMILES:
Nc1ncnc2n(CC3CCNCC3)nc(-c3ccc4cc(OCC=C)ccc4c3)c12
Structure:
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