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Target
Adenosine receptor A2a
Ligand
BDBM539137
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
IC50
3.50±n/a nM
Citation
 Pham, SM; Kankanala, J; Jadhavar, PS; Mulik, BM; Khan, F; Ramachandran, SA 1,8-naphthyridinone compounds and uses thereof US Patent  US11254670 Publication Date 2/22/2022 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM539137
Synonyms:
US11254670, Compound 7
Type:
Small organic molecule
Emp. Form.:
C22H18ClN3O2
Mol. Mass.:
391.85
SMILES:
CC(C)n1cc(cc(Cl)c1=O)-c1cc2c(nc1-c1ccccc1)[nH]ccc2=O
Structure:
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