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Target
Hsp90 chaperone protein kinase-targeting subunit
Ligand
BDBM551797
Substrate
n/a
Meas. Tech.
FP-based equilibrium competition assay
EC50
48.0±n/a nM
Citation
 Brown, LE; Huang, DS; Cowen, LE; Whitesell, L; Marcyk, P Hsp90 inhibitors and uses thereof US Patent  US11312722 Publication Date 4/26/2022 
Target
Name:
Hsp90 chaperone protein kinase-targeting subunit
Synonyms:
F5H9H0_CRYNB
Type:
Protein
Mol. Mass.:
57233.28
Organism:
Filobasidiella neoformans
Description:
F5H9H0
Residue:
505
Sequence:
MPLNYSKWDMLELSDDSDIEEHPNVDKKSMIRWKQRDIHEKREARKLLISKLKSELSLNSVLRPRIETIISGLSSSGLDHYRAVQRRMKEDPSPEKPETGAPNQPTYDMMLSQLLSDVFREGAWLVEGGRIEGNGVLYNGKKVDDNTGLPDWATAEVPEGKKELLAEKLEQRLRWHVSELNRRDEQVKKEIEKEEGELKKKITSDDIHEGWSSSKIAPPKPSVWDETPRPKKDKKTEKVETIEVLNPKASSSAAPVAPATEDTDDEEDFGPLSPAGRAFAQIPLGDFEKAYDFIKNDSSVLSSSTHDSLLAEAFDAERRGDKSLAMRCVHQSLLVNYCRQLGKDGVGLFFQKMIQKNPKSITMFNEDFQRTYNRIATRTREILAEEAAAGPSGEREQIQLVATDPNMTIAFNLPDGPPPEKILLEGEGVEELDMEQVRAWLQRKWEIFKSFPPRFQEALQTENLDKVNQALGDMKVSEAEKIVELLQEGGMLSFSEKGVRDMTNQ
  
Inhibitor
Name:
BDBM551797
Synonyms:
US11312722, Compound 87
Type:
Small organic molecule
Emp. Form.:
C23H21F3N6O3
Mol. Mass.:
486.4464
SMILES:
Oc1cc(O)c(C(=O)N2CC3NN=CC3C2)c(Nc2ccnn2Cc2ccc(cc2)C(F)(F)F)c1 |c:12|
Structure:
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