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Target
Anoctamin-1
Ligand
BDBM509654
Substrate
n/a
Meas. Tech.
Automated Whole-Cell Patch Clamp Assay
EC50
230±n/a nM
Citation
 Collingwood, S; Mccarthy, C; Hargrave, JD; Hay, DA; Schofield, TB; Ellam, S; Buxton, CS; Habgood, M; Ingram, PN; Ma, CY; Napier, SC; Shaikh, AK; Smith, MR; Stimson, CC; Walker, ER Compounds US Patent  US11364246 Publication Date 6/21/2022 
Target
Name:
Anoctamin-1
Synonyms:
ANO1 | ANO1_HUMAN | DOG1 | Discovered on gastrointestinal stromal tumors protein 1 | ORAOV2 | Oral cancer overexpressed protein 2 | TAOS2 | TMEM16A | Transmembrane protein 16A | Tumor-amplified and overexpressed sequence 2
Type:
PROTEIN
Mol. Mass.:
114103.63
Organism:
Homo sapiens (Human)
Description:
ChEMBL_828184
Residue:
986
Sequence:
MRVNEKYSTLPAEDRSVHIINICAIEDIGYLPSEGTLLNSLSVDPDAECKYGLYFRDGRRKVDYILVYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKKMYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSFFDSKTRSTIVYEILKRTTCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEFNDRKLLYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATMDENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKEKRRHIPEESTNKWKQRVKTAMAGVKLTDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLGVIIYRISMAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLKQQSPPDHEECVKRKQRYEVDYNLEPFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRAKDIGIWYNILRGIGKLAVIINAFVISFTSDFIPRLVYLYMYSKNGTMHGFVNHTLSSFNVSDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSENKYDISKDFWAVLAARLAFVIVFQNLVMFMSDFVDWVIPDIPKDISQQIHKEKVLMVELFMREEQDKQQLLETWMEKERQKDEPPCNHHNTKACPDSLGSPAPSHAYHGGVL
  
Inhibitor
Name:
BDBM509654
Synonyms:
US11364246, Example 8.3 | US20200361871A1, Example 8.3
Type:
Small organic molecule
Emp. Form.:
C24H27ClN4O5
Mol. Mass.:
486.948
SMILES:
CC(C)(C)OC(=O)N1C[C@H]2[C@@H](C1)[C@@H]2NC(=O)c1cc(NC(=O)Cc2cc(Cl)ccc2O)ccn1 |r|
Structure:
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