Reaction Details
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Induced myeloid leukemia cell differentiation protein Mcl-1 [173-329]/Phorbol-Phorbol-12-myristate-13-acetate-induced protein 1 [26-43]
Ligand
BDBM562379
Substrate
n/a
Meas. Tech.
Protein-Protein Interaction Assay
IC50
0.740±n/a nM
Citation
Furst, L; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Wei, G; McCarren, PR; Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Mönning, U; Nowak-Reppel, K Macrocyclic indole derivatives US Patent US11401278 Publication Date 8/2/2022 More Info.:
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [173-329]/Phorbol-Phorbol-12-myristate-13-acetate-induced protein 1 [26-43]
Synonyms:
MCL-1/Noxa BH3
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [173-329]
Synonyms:
BCL2L3 | MCL1 | MCL1_HUMAN
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
17924.29
Organism:
Human
Description:
Q07820[173-329]
Residue:
157
Sequence:
ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIR
Component 2
Name:
Phorbol-Phorbol-12-myristate-13-acetate-induced protein 1 [26-43]
Synonyms:
APR_HUMAN | NOXA | PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1 (NOXA)(BH3)
Type:
n/a
Mol. Mass.:
2208.61
Organism:
Human
Description:
Q13794[26-43]
Residue:
18
Sequence:
ATQLRRFGDKLNFRQKLL
Inhibitor
Name:
BDBM562379
Synonyms:
(rac)-4-chloro-7-{3-[(6-fluoro-1-naphthyl)oxy]propyl}-2,3-dimethyl-11,12,14,15-tetrahydro-2H,10H-pyrazolo[3′,4′:4,5][1,2,8]thiadiazacycloundecino[6,7,8-hi]indole-8-carboxylic acid 13,13-dioxide | US11401278, Example 50 | US11401278, Example 51 | US11401278, Example 52
Type:
Small organic molecule
Emp. Form.:
C31H30ClFN4O5S
Mol. Mass.:
625.11
SMILES:
Cc1c-2c(CNS(=O)(=O)CCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C
Structure:
