Reaction Details Report a problem with these data
Target
Isoform APP695 of Amyloid-beta precursor protein [K595N,M596L]
Ligand
BDBM50502712
Substrate
n/a
Meas. Tech.
Cellular gamma-Secretase Assay
EC50
26.0±n/a nM
Citation
Bartels, B; Cook, XA; Ratni, H; Reutlinger, M; Vifian, W Triazolo-azepine derivatives US Patent US11440915 Publication Date 9/13/2022
More Info.:
Target
Name:
Isoform APP695 of Amyloid-beta precursor protein [K595N,M596L]
Synonyms:
A4 | A4_HUMAN | AD1 | APP | Amyloid-beta precursor protein | Amyloid-beta precursor protein (PreA4 695) [K595N,M596L] | Isoform APP695 (K595N,M596L)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
78580.06
Organism:
Homo sapiens (Human)
Description:
P05067-4(K595N,M596L)
Residue:
695
Sequence:
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVNLDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN