Reaction Details
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Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide
Ligand
BDBM572173
Substrate
n/a
Meas. Tech.
MCL-1/Noxa BH3 Peptide (MCL-1 Assay)
IC50
0.690±n/a nM
Citation
Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Macrocyclic chlorine substituted indole derivatives US Patent US11447504 Publication Date 9/20/2022 More Info.:
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide
Synonyms:
MCL-1/Noxa BH3 Peptide
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 3 components.
Component 1
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]
Synonyms:
BCL2L3 | MCL1 | MCL1_HUMAN
Type:
n/a
Mol. Mass.:
17056.39
Organism:
Human
Description:
Q07820[173-321]
Residue:
149
Sequence:
ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV
Component 2
Name:
Maltose/maltodextrin import ATP-binding protein MalK
Synonyms:
MALK_ECOLI | malK
Type:
Protein
Mol. Mass.:
40990.98
Organism:
Escherichia coli (strain K12)
Description:
P68187
Residue:
371
Sequence:
MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV
Component 3
Name:
Phorbol-12-myristate-13-acetate-induced protein 1 [17-23,25-42,C24V]
Synonyms:
APR_HUMAN | Immediate-early-response protein APR | NOXA | PMA-induced protein 1 | PMAIP1 | Protein Noxa
Type:
Protein
Mol. Mass.:
3072.54
Organism:
Human
Description:
Biotin-PEG2-PEG2-PAELEVE-Nva-ATQLRRFGDKLNFRQKLL-amide
Residue:
26
Sequence:
PAELEVEVATQLRRFGDKLNFRQKLL
Inhibitor
Name:
BDBM572173
Synonyms:
4-chloro-2,3-dimethyl-7-[3-(naphthalen-1-yloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo-[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid-N-ethylethanamine Salt (Enantiomer 1) | US11447504, Example 26 | US11447504, Example 27 | US11478451, Example 27
Type:
Small organic molecule
Emp. Form.:
C31H30ClN3O4
Mol. Mass.:
544.041
SMILES:
Cc1[nH]nc2COCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34
Structure:
