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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM458719
Substrate
n/a
Meas. Tech.
Binding Affinity Assay
Ki
0.410±n/a nM
Citation
 Yoshinaga, H; Ikuma, Y; Ikeda, J; Adachi, S; Mitsunuma, H; Aihara, Y; Besnard, J; Bell, AS Substituted lactams showing serotonin 5-HT receptor activity US Patent  US11466007 Publication Date 10/11/2022 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM458719
Synonyms:
5-{2-[4-(1,2-Benzoisoxazol-3-yl)piperidin-1-yl]ethyl}-3-bromo-1,5,6,7-tetrahydro-4H-pyrazolo[4,3-c]pyridin-4-one | US10745401, Example 192 | US11466007, Example 192
Type:
Small organic molecule
Emp. Form.:
C20H22BrN5O2
Mol. Mass.:
444.325
SMILES:
Brc1n[nH]c2CCN(CCN3CCC(CC3)c3noc4ccccc34)C(=O)c12
Structure:
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