Reaction Details
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Calcium/calmodulin-dependent protein kinase type 1D
Ligand
BDBM585209
Substrate
n/a
Meas. Tech.
Biochemical CaMK1D Enzymatic Activity Assay
IC50
10.00±n/a nM
Citation
Fischer, P; Fromont, C; Stevenson, B; Butterworth, S; Iacobini, G; Greco, G; Sanz, MG; Jones, H; Kaur, D Kinase inhibitors US Patent US11530193 Publication Date 12/20/2022 More Info.:
Target
Name:
Calcium/calmodulin-dependent protein kinase type 1D
Synonyms:
CAMK1D | CAMKID | CaM kinase I delta | KCC1D_HUMAN
Type:
PROTEIN
Mol. Mass.:
42916.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586559
Residue:
385
Sequence:
MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAPSTLCSFISSSSGVSGVGAERRPRPTTVTAVHSGSK
Inhibitor
Name:
BDBM585209
Synonyms:
US11530193, Example 125
Type:
Small organic molecule
Emp. Form.:
C25H37N7O2
Mol. Mass.:
467.607
SMILES:
CO[C@H]1CC[C@@H](CC1)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(n1)C(C)C |r,wU:5.8,wD:25.27,2.1,(7.49,-5.12,;6.16,-5.89,;4.82,-5.12,;4.82,-3.58,;3.49,-2.81,;2.16,-3.58,;2.16,-5.12,;3.49,-5.89,;.82,-2.81,;.82,-1.27,;-.51,-.5,;-.51,1.04,;-1.84,1.81,;-3.18,1.04,;-4.51,1.81,;-4.51,3.35,;-3.18,4.12,;-1.84,3.35,;-.51,4.12,;.82,3.35,;-.51,5.66,;-5.84,1.04,;-5.84,-.5,;-7.18,-1.27,;-8.51,-.5,;-8.51,1.04,;-9.85,1.81,;-7.18,1.81,;-1.84,-1.27,;-1.84,-2.81,;-.51,-3.58,;-3.18,-3.58,;-3.18,-5.12,;-4.51,-2.81,)|
Structure:
