Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit gamma-1
Ligand
BDBM588629
Substrate
n/a
Meas. Tech.
Steroid Inhibition of TBPS Binding
IC50
<10±n/a nM
Citation
 Martinez Botella, G; Salituro, FG; Robichaud, AJ; Harrison, BL Compositions and methods for treating CNS disorders US Patent  US11542297 Publication Date 1/3/2023 
Target
Name:
Gamma-aminobutyric acid receptor subunit gamma-1
Synonyms:
Benzodiazepine receptors | Benzodiazepine receptors; peripheral & central | GABA receptor gamma-1 subunit | GBRG1_RAT | Gabrg1
Type:
PROTEIN
Mol. Mass.:
53557.84
Organism:
Rattus norvegicus
Description:
ChEMBL_193817
Residue:
465
Sequence:
MGSGKVFLFSPSLLWSQTRGVRLIFLLLTLHLGNCIDKADDEDDEDLTMNKTWVLAPKIHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWSDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGLRNSTEISHTISGDYIIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSNNKGKTTRDRKLKSKTSVSPGLHAGSTLIPMNNISMPQGEDDYGYQCLEGKDCATFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL
  
Inhibitor
Name:
BDBM588629
Synonyms:
US11542297, Compound 32
Type:
Small organic molecule
Emp. Form.:
C24H38N4O2
Mol. Mass.:
414.5841
SMILES:
Cc1nnn(CC(=O)[C@H]2CC[C@H]3[C@@H]4CC[C@@H]5C[C@](C)(O)CC[C@]5(C)[C@H]4CC[C@]23C)n1 |r|
Structure:
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