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Target
Gamma-aminobutyric acid receptor subunit gamma-1
Ligand
BDBM586079
Substrate
n/a
Meas. Tech.
Steroid Inhibition of TBPS Binding
IC50
<10±n/a nM
Citation
 Martinez Botella, G; Salituro, FG; Robichaud, AJ; Harrison, BL Compositions and methods for treating CNS disorders US Patent  US11542297 Publication Date 1/3/2023 
Target
Name:
Gamma-aminobutyric acid receptor subunit gamma-1
Synonyms:
Benzodiazepine receptors | Benzodiazepine receptors; peripheral & central | GABA receptor gamma-1 subunit | GBRG1_RAT | Gabrg1
Type:
PROTEIN
Mol. Mass.:
53557.84
Organism:
Rattus norvegicus
Description:
ChEMBL_193817
Residue:
465
Sequence:
MGSGKVFLFSPSLLWSQTRGVRLIFLLLTLHLGNCIDKADDEDDEDLTMNKTWVLAPKIHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWSDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGLRNSTEISHTISGDYIIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSNNKGKTTRDRKLKSKTSVSPGLHAGSTLIPMNNISMPQGEDDYGYQCLEGKDCATFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL
  
Inhibitor
Name:
BDBM586079
Synonyms:
US11530237, Compound 260 | US11542297, Compound 260
Type:
Small organic molecule
Emp. Form.:
C29H46N4O3
Mol. Mass.:
498.7005
SMILES:
CCCN(C)C(=O)c1cnn(CC(=O)[C@H]2CC[C@H]3[C@@H]4CC[C@@H]5C[C@](C)(O)CC[C@]5(C)[C@H]4CC[C@]23C)n1 |r|
Structure:
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