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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM597059
Substrate
n/a
Meas. Tech.
TR-FRET Binding Assay
Ki
<0.200±n/a nM
Citation
 Lee, T; Tarr, JC; Jeon, K; Salovich, JM; Shaw, S; Veerasamy, N; Kim, K; Christov, PP; Olejniczak, ET; Zhao, B; Fesik, SW; Bian, Z Substituted indole Mcl-1 inhibitors US Patent  US11596639 Publication Date 3/7/2023 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Human
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM597059
Synonyms:
US11596639, Example 658
Type:
Small organic molecule
Emp. Form.:
C40H39Cl2N5O4
Mol. Mass.:
724.675
SMILES:
C[C@@H]1CN(C(=O)c2c(CCCOc3cc(C)c(Cl)c(C)c3)c3ccc(Cl)c(-c4c(C)nn(C)c4C)c3n12)c1cc(C)cc2cc(cnc12)C(O)=O |r,wD:1.0,(-.86,5.2,;-.86,3.66,;.67,3.82,;1.58,2.57,;.95,1.17,;1.85,-.09,;-.58,1.01,;-1.49,-.24,;-1.01,-1.71,;.49,-2.04,;.98,-3.5,;2.48,-3.83,;2.97,-5.29,;4.49,-5.55,;5.01,-7,;6.52,-7.32,;4.02,-8.18,;4.49,-9.65,;2.51,-7.91,;1.54,-9.11,;1.98,-6.47,;-2.95,.24,;-4.28,-.53,;-5.62,.24,;-5.62,1.78,;-6.99,2.48,;-4.28,2.55,;-4.28,4.09,;-5.53,4.99,;-6.99,4.51,;-5.05,6.46,;-3.51,6.46,;-2.74,7.79,;-3.04,4.99,;-1.57,4.51,;-2.95,1.78,;-1.49,2.25,;3.11,2.73,;4.05,1.51,;5.57,1.71,;6.51,.49,;6.16,3.14,;5.23,4.36,;5.82,5.78,;4.88,7,;3.35,6.8,;2.76,5.38,;3.7,4.16,;5.47,8.42,;4.53,9.65,;6.99,8.63,)|
Structure:
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